脾动脉部分栓塞治疗肝硬化合并脾功能亢进患者的效果

Effect of Partial Splenic Artery Embolization on Patients with Cirrhosis Complicated by Hypersplenism

目的:评价部分性脾动脉栓塞术(PSE)治疗肝硬化合并脾功能亢进患者的临床疗效及安全性。方法:回顾2013年11月—2015年1月行部分性脾动脉栓塞术的患者40例,对比分析患者PSE治疗前后血细胞和肝功能相关指标含量的统计学差异,分析患者术后并发症发生率的情况。结果:PSE术后脾亢症状迅速缓解,血小板和白细胞明显回升。随访1年,40例中38例(占95.0%)存活,2例(占5.0%)发生死亡(1例死于肝功能衰竭,1例死于原发性肝癌)。存活患者血小板相对稳定,肝功能均为Child-Pugh A级。结论:PSE治疗肝硬化合并脾功能亢进安全且有效,其对患者血小板及白细胞影响相对稳定且有效。

Objective:To evaluate the clinical efficacy of partial splenic embolization(PSE)for hypersplenism due to cirrhosis.Methods:40 patients who underwent partial splenic artery embolization from November 2013 to January 2015 were retrospectively reviewed.Statistical differences in blood cell and liver function related indexes of PSE patients before and after treatment were compared and analyzed,and statistical differences in the incidence of postoperative complications between the two groups were compared.Results:After PSE,the symptoms of hypersplenism were quickly relieved,and platelets and white blood cells were significantly increased.After 1 year of follow-up,38(95.0%)of the 40 patients survived and 2(5.0%)died(1 died of liver failure and 1 died of primary liver cancer).The surviving patients had relatively stable platelets and Child-Pugh grade A liver function.Conclusion:PSE is safe and effective in the treatment of cirrhosis complicated by hypersplenism,and its effect on platelets and white blood cells is relatively stable and limited.