白癜风患者焦虑抑郁状态与血浆β-内啡肽水平相关性研究

Study on the correlation between anxiety and depression status and plasmaβ-endorphin levels in patients with vitiligo

目的研究白癜风患者焦虑抑郁状态与血浆β-内啡肽水平的相关性。方法选取2019年1-10月武汉市第一医院皮肤科收治的白癜风患者85例作为观察组,另选取健康体检者100例作为对照组,采用汉密尔顿焦虑量表14项版(HAMA-14)、汉密尔顿抑郁量表24项版(HAMD-24)及症状自评量表(SCL-90)进行情绪评分并评定焦虑或抑郁状态的严重程度,应用酶联免疫吸附试验(ELISA)测定2组血浆β-内啡肽表达水平。结果观察组患者HAMA、HAMD、SCL-90评分,以及血浆β-内啡肽表达水平均高于对照组,差异均有统计学意义(P<0.05)。观察组中进展期患者血浆β-内啡肽表达水平明显高于稳定期患者;观察组中节段型患者血浆β-内啡肽表达水平显著高于寻常型患者;观察组中皮损位于暴露部位患者血浆β-内啡肽表达水平明显高于非暴露部位患者;观察组焦虑患者血浆β-内啡肽表达水平明显高于非焦虑患者;观察组抑郁患者血浆β-内啡肽表达水平明显高于无抑郁症状表现患者。结论焦虑、抑郁等精神障碍可能通过神经-内分泌-免疫网络参与了白癜风的发病,患者血浆中β-内啡肽水平可能与患者情绪互相影响并作用于白癜风。

Objective To study the relationship between anxiety,depression and plasmaβ-endorphin levels in patients with vitiligo.Methods From January to October 2019,85 cases of vitiligo patients admitted to the Department of Dermatology of Wuhan First Hospital were selected as the observation group,and 100 healthy subjects were selected as the control group.The 14-item version of the Hamilton Anxiety Scale(HAMA-14),the 24-item version of the Hamilton Depression Scale(HAMD-24)and the Symptom Self-Rating Scale(SCL-90)were used to score mood and assess the severity of anxiety or depression.Enzyme-linked immunosorbent assay(ELISA)was used to determine the expression levels of plasmaβ-endorphin in the two groups.Results The HAMA,HAMD,SCL-90 scores and plasmaβ-endorphin expression levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The expression level of plasmaβ-endorphin in advanced patients in the observation group was significantly higher than that in patients with stable stage;the expression level of plasmaβ-endorphin in patients with mid-segmental type in the observation group was significantly higher than that of ordinary type patients.In the observation group,the expression level of plasmaβ-endorphin in patients with skin lesions in exposed parts was significantly higher than that in patients with non-exposed parts.The expression level of plasmaβ-endorphin in anxious patients in the observation group was significantly higher than that in non-anxious patients.The expression level of plasmaβ-endorphin in depressed patients in the observation group was significantly higher than that in non-depressive patients.Conclusion Mental disorders such as anxiety and depression may participate in the pathogenesis of vitiligo through the neuro-endocrine-immune network.The level ofβ-endorphin in the patient's plasma may interact with the patient's mood and act on the pathogenesis of vitiligo.