摘要
目的:研究Bcl-2(B-cell leukemia-2)蛋白和p53蛋白在牙龈增生中的表达,探讨其与增生牙龈中抗凋亡作用机制的相关性。方法:选择符合临床诊断的11例炎症性牙龈增生患者作为实验组,正常牙龈组织11例作为对照组;通过免疫组织化学法探究增生牙龈组织和正常牙龈组织中Bcl-2蛋白和p53蛋白的表达情况。结果:增生牙龈组织中Bcl-2蛋白和p53蛋白的阳性表达均明显高于正常牙龈组织(P<0.05)。结论:Bcl-2蛋白和p53蛋白在牙龈增生中发挥重要作用,抗凋亡抑制作用参与了牙龈增生的发病过程。
Objective:To study the expressions of Bcl-2 protein and p53 protein in gingival hyperplasia,and to explore their correlation with the anti-apoptotic mechanism of gingival hyperplasia.Methods:11 cases of gingival hyperplasia caused by inflammation in accordance with the clinical diagnosis were selected as the experimental group and 11 cases of normal gingival tissue as the control group.The expressions of Bcl-2 and p53 proteins in the hyperplastic and normal gingival tissue were investigated by immunohistochemistry.Results:The positive expressions of Bcl-2 protein and p53 protein in hyperplastic gingival tissue were both significantly higher than those in normal gingival tissue(P<0.05).Conclusion:Bcl-2 protein and p53 protein play an important role in gingival hyperplasia,and the anti-apoptosis may involve in the pathogenesis of gingival hyperplasia.
作者
张睿
刘娇艳
李德纯
张明珠
彭艺
税艳青
ZHANG Rui;LIU Jiaoyan;LI Dechun;ZHANG Mingzhu;PENG Yi;SHUI Yanqing(Department of Periodontics, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650100, China;School of Stomatology, Kunming Medical University, Kunming 650500, China)
出处
《口腔医学研究》
CAS
CSCD
北大核心
2021年第4期300-303,共4页
Journal of Oral Science Research
基金
昆明医科大学大学生创新性实验计划省级项目(329)。
