替罗非班不同给药途径治疗急性心肌梗死的疗效

Efficacy of different administration routes of tirofiban in the treatment of acute myocardial infarction

目的:分析替罗非班不同给药途径治疗急性心肌梗死的疗效。方法:选取急性心肌梗死患者67例作为研究对象,开展回顾性治疗研究。患者均行PCI治疗,根据患者术中替罗非班给药途径进行分组,其中静脉组34例,冠脉组33例。静脉组术中行替罗非班静脉注射给药,冠脉组术前行冠状动脉注射给药。对比两组的临床疗效,3级血流、心肌灌注3级占比,心室功能指标及不良事件发生率。结果:冠脉组治疗后左室舒张末、收缩末内径较静脉组降低明显,左室射血分数提升显著;冠脉组治疗后心脏不良事件发生率低于静脉组(P<0.05)。结论:冠状动脉注射给药治疗急性心肌梗死的效果优于静脉注射给药。

Objective:To analyze the efficacy of different administration routes of tirofiban in the treatment of acute myocardial infarction.Methods:A total of 67 patients with acute myocardial infarction were selected as the research subjects,and the retrospective treatment studies were carried out.All the patients underwent PCI and were divided into a vein group(34 cases,giving intravenous tirofiban injection)and a coronary artery group(33 cases,giving coronary artery tirofiban injection)based on their tirofiban administration routes.The clinical efficacy,the proportion of grade 3 blood flow and myocardial perfusion grade 3,the ventricular function indexes and the incidence of adverse events were compared.Results:The left ventricular end diastolic and end systolic diameters were decreased,the left ventricular ejection fraction was significantly increased in the coronary artery group and the incidence of cardiac adverse events was significantly lower in the coronary artery group than the vein group after treatment(P<0.05).Conclusion:The efficacy of tirofiban by coronary artery injection is much better than intravenous injection in the treatment of acute myocardial infarction.