子宫内膜炎治疗中联合应用甲羟孕酮片和抗生素的效果观察

Effect of Medroxy-Progesterone and Antibiotics in the Treatment of Endometritis

目的:观察分析联合应用甲羟孕酮片和抗生素治疗子宫内膜炎患者的临床效果。方法:选择我院2018年1月—2019年8月收治的子宫内膜炎患者128例作为本次的研究对象,随机分为相同例数的两个组别:治疗组和对照组,每组各有患者64例。对照组患者应用多西环素与甲硝唑治疗,治疗组患者在对照组治疗措施的基础上加用甲羟孕酮片治疗。比较两组患者的临床疗效、下腹疼痛缓解时间、白带增多缓解时间、阴道出血缓解时间及治疗前后血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶(MMP-9)水平。结果:在临床治疗总有效率方面,治疗组患者明显高于对照组患者(93.75%VS 81.25%),差异有显著性(P<0.05)。在下腹疼痛缓解时间、白带增多缓解时间、阴道出血缓解时间方面,治疗组低于对照组,差异有显著性(P<0.05)。治疗后,两组MMP-9、TNF-α等水平均降低,IL-2水平均升高(P<0.05)。治疗组治疗后MMP-9、TNF-α等水平低于对照组,IL-2水平高于对照组(P<0.05)。结论:联合应用甲羟孕酮片和抗生素治疗子宫内膜炎患者的临床效果显著,患者临床症状改善较快,机体炎症反应水平降低明显,具有临床推广的价值。

Objective:To observe and analyze the clinical effect of medroxy-progesterone tablets and antibiotics in the treatment of endometritis.Method:128 cases of endometritis admitted to our hospital from January 2018 to August 2019 were selected as the study objects,and randomly divided into two groups with the same number of cases:the treatment group and the control group,with 64 patients in each group.The patients in the treatment group were treated with doxycycline and metronidazole,and the patients in the treatment group were treated with medroxy-progesterone tablets on the basis of the treatment measures in the control group.The clinical effect,the time of relieving pain in lower abdomen,the time of relieving leucorrhea,the time of relieving vaginal bleeding and the levels of IL-2,TNF-α and MMP-9 were compared before and after treatment.Result:The total effective rate of clinical treatment in the treatment group was significantly higher than that in the control group(93.75%VS 81.25%)(P<0.05).The difference was significant(P<0.05).After treatment,the levels of MMP-9 and TNF-α decreased and the level of IL-2 increased in both groups(P<0.05).The levels of MMP-9 and TNF-α in the treatment group were lower than those in the control group,and the levels of IL-2 were higher than those in the control group(P<0.05).Conclusion:The combination of medroxy-progesterone tablets and antibiotics in the treatment of endometritis has a significant clinical effect.The clinical symptoms of the patients are improved rapidly,and the level of inflammatory response is reduced significantly.It has the value of clinical promotion.