阿奇霉素、左氧氟沙星治疗慢性支气管炎的效果和安全性分析

Analysis of the Efficacy and Safety of Azithromycin and Levofloxacin in the Treatment of Chronic Bronchitis

目的探究阿奇霉素、左氧氟沙星治疗慢性支气管炎的效果和安全性。方法方便选择2017年10月-2019年10月期间该院接诊的86例慢性支气管炎患者作为分析对象设计前瞻对照实验,依据就诊的先后顺序将患者随机分为观察组和对照组,各43例,入院后给予患者止咳、化痰等常规对症治疗,对照组患者口服阿奇霉素进行治疗,观察组患者在对照组患者的基础上口服左氧氟沙星进行治疗,观察两组患者临床治疗效果。结果观察组患者阿奇霉素联合左氧氟沙星治疗总有效率为95.35%,对照组患者阿奇霉素治疗总要有效率为81.40%,差异有统计学意义(χ^(2)=4.074,P=0.044);观察组患者发热(2.32±0.61)d、咳嗽(4.12±1.75)d、咳痰(3.01±0.46)d及呼吸困难(3.65±0.80)d等临床症状缓解时间均短于对照组患者(2.76±0.58)d、(5.07±1.84)d、(3.97±0.88)d、(4.79±0.74)d,差异有统计学意义(P<0.05);使用阿奇霉素联合左氧氟沙星治疗的观察组患者不良反应发生率为6.98%,单独使用阿奇霉素治疗的对照组患者不良反应发生率为4.65%,差异无统计学意义(χ^(2)=0.212,P=0.645)。结论阿奇霉素联合左氧氟沙星治疗慢性支气管炎效果明显优于单独使用阿奇霉素,能够提高患者临床治疗总有效率,使患者临床症状得到快速有效的缓解,且不增加患者药物不良反应。

Objective To explore the efficacy and safety of azithromycin and levofloxacin in the treatment of chronic bronchitis. Methods 86 patients with chronic bronchitis admitted to the hospital from October 2017 to October 2019 were conveniently selected as the analysis objects to design a prospective controlled experiment. According to the order of visits,the patients were randomly divided into observation group and control group with 43 cases each. After admission, patients were given conventional symptomatic treatments such as cough relieving and phlegm resolving. The control group was treated with azithromycin orally, and the observation group was treated with levofloxacin on the basis of the control group.The clinical treatment effects of the two groups were observed. Results The total effective rate of azithromycin combined with levofloxacin in the observation group was 95.35%, and the total effective rate of azithromycin in the control group was81.40%, the difference was statistically significant(χ^(2)=4.074,P=0.044);The observation group patients had fever(2.32±0.61)d,cough(4.12±1.75)d, expectoration(3.01±0.46)d and dyspnea(3.65±0.80)d and other clinical symptoms relieved time was shorter than the control group(2.76±0.58)d,(5.07±1.84)d,(3.97±0.88)d,(4.79±0.74)d, the difference was statistically significant(P <0.05);The adverse reaction rate of patients in the observation group treated with azithromycin combined with levofloxacin was 6.98%, and the adverse reaction rate of patients in the control group treated with azithromycin alone was4.65%. The difference was statistically significant(χ^(2)=0.212,P=0.645). Conclusion The effect of azithromycin combined with levofloxacin in the treatment of chronic bronchitis is significantly better than that of azithromycin alone. It can improve the total effective rate of clinical treatment of patients, and relieve the clinical symptoms of patients quickly and effectively without increasing the adverse drug reactions of patients.