摘要
目的:探讨地中海贫血铁过载脏器的MRI影像学特征分析及其与MRI T2*值的关系。方法:回顾性选取90例重型β地中海贫血患者作为研究对象,所有患者均进行了心脏、肝脏、胰腺、肾脏器官的MRI检查,同时测定了血清铁蛋白(SF),收集其临床资料,分析各器官MRI T2*值之间及与SF间的关系。结果:90例患者SF平均值为(2596.13±982.36)μg/L。根据SF进行铁过载程度的分组,三组间肝脏与胰腺T2*值存在统计学差异,均随着SF过载程度的加重而降低(P<0.05)。pearson相关性分析结果显示,SF与肝脏及胰腺T2*值呈显著负相关(P<0.05),与心脏、肾脏以及脾脏的T2*值均无相关性(P>0.05)。肝脏和脾脏、肝脏和胰腺间的T2*值呈显著正相关(P<0.05),其他器官间的T2*值均无相关性(P>0.05)结论:重型β地中海贫血患者容易发生心脏、肝脏等器官铁过载,过载脏器MRI T2*值呈现减低,其中血清铁负荷与肝脏、胰腺T2*值存在显著负相关。
Objective:To investigate the imaging characteristics of iron-overloaded organs and its relationship with T2** measurement on MRI in thalassemia.Methods:Ninety patients withβ-thalassemia major were included retrospectively.All patients underwent MRI examinations of the heart,liver,pancreas,and kidney;meanwhile,serum ferritin(SF)was measured,and clinical data were collected.The relationship between MRI T2* measurement and SF in these organs was analyzed.Results:The mean SF level was(2596.13±982.36)μg/L in the 90 patients.The subjects were divided into three groups according to severity of iron overloading classified by the SF levels.The T2* measurements of the liver and pancreas statistically differed across the three groups,and all decreased with the increase of SF overload(P<0.05).Pearson correlation analysis showed that SF was significantly negatively correlated with T2* values of the liver and pancreas(P<0.05),but was not correlated with those of the heart,kidney,and spleen(P>0.05).There were significantly positive correlations in T2* values between the liver and spleen,and between the liver and pancreas(P<0.05),but not among other organs(P>0.05).Conclusion:Patients withβ-thalassemia major are prone to iron overload in organs such as the heart and liver.The MRI T2* meaurement is lower in iron-overloaded organs.There are significant negative correlations between serum iron load and the T2* measurements in the liver and pancreas.
作者
梁庚
黄创基
曾志泉
龙永德
Liang Geng;Huang Chuangji;Zeng Zhiquan;Long Yongde(Department of Radiology,2.Department of Pediatrics,3.Department of Clinical Laboratory Medicine,Luoding Hospital of Traditional Chinese Medicine,Yunfu 527200,Guangdong,China)
出处
《广州医科大学学报》
2021年第1期41-43,共3页
Academic Journal of Guangzhou Medical University
基金
2019年度云浮市医药卫生科研立项(云卫函〔2019〕221号-68)。
关键词
地中海贫血
铁过载
核磁共振
血清铁蛋白
Thalassemia
iron overload
nuclear magnetic resonance
serum ferritin