肝门部胆管癌术前胆管扩张程度与预后的相关性研究

Correlation between preoperative bile duct dilatation evaluation and prognosis of hilar cholangiocarcinoma

目的评价肝门部胆管癌(hilar cholangiocarcinoma,HC)术前胆管扩张程度与预后的相关性。方法回顾性分析2009年1月~2013年12月在天津市南开医院进行根治术治疗的89例HC患者的临床资料。根据磁共振胰胆管成像(magnetic resonance cholangiopancreatography,MRCP)显示的胆管扩张程度将患者分组,分析胆道扩张程度的相关因素及胆道扩张程度对患者手术预后的影响。结果肿瘤大小(P=0.024)、Bismuth-Corltte分型(P=0.048)和肿瘤分期(P=0.013)均与胆道扩张程度相关;肿瘤分化程度(P=0.002),R_(0)切除与否(P=0.002)和胆道扩张程度(P<0.001)是3年无病生存期(disease-free survival,DFS)的独立预测指标。结论对胆道扩张程度进行影像学评价有助于预测HC手术患者的预后。

Objective To evaluate the correlation between the prognosis of patients with hilar cholangiocarcinoma and the degree of bile duct dilatation in MRCP。Methods The clinical data of 89 patients with hilar cholangiocarcinoma undergoing radical operation at Tianjin Nankai Hospital from Jan 2009 to Dec 2013 were analyzed retrospectively.Results Tumor size(P=0.024),Bismuth-Corlette classification(P=0.048)and tumor stage(P=0.013)were related factors of biliary dilatation.Tumor differentiation(P=0.002),R,resection(P=0.002)and biliary dilatation(P<0.001)were independent predictors of disease-free survival(DFS).Conclusion The imaging evaluation of the degree of biliary dilatation has a certain predictive value for the prognosis of patients with hilar cholangio-carcinoma.