内皮间质转化参与异位骨化的研究进展

Research progress of endothelial-mesenchymal transition in heterotopic ossification

异位骨化(heterotopic ossification, HO)是指在正常的软组织中出现病理性骨形成,临床上常发生在关节周围的韧带、肌肉和肌腱,其引起的功能障碍会严重影响患者的生活质量。HO的发病机理目前尚不明确。血管内皮细胞可以通过内皮间质转化(endothelial-mesenchymal transition, Endo-MT)形成的间充质干细胞中间体分化为骨细胞。组织微环境中局部炎症信号因子或其他因子能够介导内皮来源间充质干细胞分化为软骨细胞和成骨细胞来诱导HO。本文将总结Endo-MT在HO方面的研究进展。

Heterotopic ossification(HO) is characterized by pathological bone formation in normal soft tissue, which occurs clinically in ligaments, muscles and tendons around joints, and the dysfunction caused by HO would seriously affect the quality of life. The pathogenesis of HO remains unclear. Vascular endothelial cells differentiate into bone cells from mesenchymal stem cell intermediate by endothelial mesenchymal transition(Endo-MT). Local inflammatory signaling factors or other factors in the tissue microenvironment mediate the differentiation of endothelium-derived mesenchymal stem cells into chondrocytes and osteoblasts so as to induce HO. This paper summarizes the research progress of Endo-MT in HO.