中药抗变态反应作用的免疫药理学实验研究进展

Research progress of immunopharmacological experiments of anti-allergic effects of Traditional Chinese Medicine

中草药治疗变态反应性疾病具有效果优、不良反应少的特点。中药复方、中药提取物和中药单体在抗变态反应的作用是多环节的,如减少和防止靶细胞脱颗粒,释放生物活性介质,抑制信号通路传导等。中药除通过调节细胞免疫和体液免疫发挥抗过变态反应作用外,还可不同程度地增强机体非特异性免疫功能,有助于某些顽固性变态反应性疾病的根除。从中草药中研制出效果优、不良反应少的抗变态反应性疾病新制剂将成为未来研究的一种趋势,具有广阔的医疗前景。

Traditional Chinese Medicine(TCM)treating allergic diseasesis effective and with few adverse reactions.The effects of TCM compound,TCM extracts and Chinese herbal monomers played the anti-allergic role in multiple stages.Such as reducing and preventing target cell degranulation,releasing biologically active mediators,and inhibiting the conduction of signal pathways.Recent studies have found that in addition to anti-allergic effects by regulating cellular and humoral immunity,TCM can also enhance the body’s non-specific immune function to different degrees and help eradicate certain intractable allergic diseases.The development of new therapeutic agents for allergic diseases with good effect and less adverse reactions from Chinese herbal medicine will become a trend in the future research and have broad medical prospects.