放疗(全脑)联合靶向治疗非小细胞肺癌脑转移的疗效

The Efficacy of Radiotherapy(Whole Brain)Combined with Targeted Therapy for Brain Metastases from Non-small Cell Lung Cancer

目的对非小细胞肺癌脑转移患者采用全脑放疗联合靶向治疗的效果进行探究。方法选择该院收治的非小细胞肺癌脑转移患者82例作为该次研究对象,选取时间段为2017年1月—2018年12月。按照随机数字表法将其划分单一组和联合组,每组41例。采用全脑放疗治疗单一组,在此基础上,采用靶向治疗对联合组进行治疗。对两组患者的治疗效果进行观察和比较。结果联合组的总有效率65.8%明显高于单一组43.9%,差异有统计学意义(χ^(2)=3.989,P<0.05);在治疗期间,联合组的不良反应率46.3%与单一组41.5%差异无统计学意义(χ^(2)=0.198,P>0.05);联合组的1年生存率73.2%明显高于单一组51.2%,差异有统计学意义(χ^(2)=3.850,P<0.05)。结论针对非小细胞肺癌脑转移患者采用全脑放疗联合靶向治疗,效果确切,能够控制其肿瘤的生长,使患者的生存时间延长,而且具有较少的不良反应,安全性较高。

Objective To explore the effect of whole brain radiotherapy combined with targeted therapy in patients with brain metastases from non-small cell lung cancer.Methods A total of 82 patients with brain metastases from non-small cell lung cancer admitted to the hospital were selected as the research subjects in this study.The selected time period was from January 2017 to December 2018.According to the random number table method,they were divided into single group and combined group,each group had 41 cases.A single group was treated with whole brain radiotherapy,and on this basis,targeted therapy was used to treat the combined group.Observed and compared the treatment effects of the two groups of patients.Results The total effective rate of 65.8%of the combined group was significantly higher than 43.9%of the single group,and the difference was statistically significant(χ^(2)=3.989,P<0.05);during the treatment period,the adverse reaction rate of the combined group was 46.3%,and the single group was 41.5%,the difference was not statistically significant(χ^(2)=0.198,P>0.05);the 1-year survival rate of the combined group was 73.2%,significantly higher than that of the single group 51.2%,and the difference was statistically significant(χ^(2)=3.850,P<0.05).Conclusion For patients with brain metastases from non-small cell lung cancer,whole-brain radiotherapy combined with targeted therapy has a definite effect.It can control the growth of their tumors,prolong the survival time of patients,and have fewer adverse reactions and higher safety.