消化道早癌患者内镜下黏膜剥离术治疗对患者临床疗效与患者预后的影响

Effect of Endoscopic Mucosal Dissection for Patients with Early Gastrointestinal Cancer on Clinical Efficacy and Prognosis

目的探析消化道早癌患者应用内镜下黏膜剥离术(ESD)治疗对临床疗效及预后的影响。方法选取2018年1月—2020年5月该院收治的50例消化道早癌患者为研究对象,根据不同手术方法分成对照组(25例)与实验组(25例)。对照组应用内镜下黏膜切除术(EMR)治疗,实验组应用ESD治疗,对比两组手术指标情况、疼痛程度、手术效果及预后。结果实验组手术时间为(78.52±16.57)min,对照组为(75.38±18.63)min,差异无统计学意义(t=0.630,P>0.05);实验组术中出血量、创面愈合时间、住院时间为(57.59±5.37)mL、(7.55±2.03)d、(6.40±1.48)d,对照组为(80.30±5.36)mL、(12.36±2.52)d、(11.98±1.52)d,差异有统计学意义(t=14.970、7.430、13.150,P<0.05)。实验组术后1 d、3 d疼痛评分为(5.02±1.12)分、(2.21±0.76)分,对照组为(6.33±1.65)分、(3.32±0.87)分,差异有统计学意义(t=3.280、4.800,P<0.05)。实验组完全切除率、并发症发生率、复发率为96.00%、4.00%、4.00%,对照组为68.00%、32.00%、32.00%,差异有统计学意义(χ^(2)=4.878、4.878、4.878,P<0.05)。结论消化道早癌患者应用ESD治疗的效果更加理想,不仅可以提高完全切除率,还可以减轻疼痛,减少并发症与复发。

Objective To explore the effect of endoscopic mucosal dissection(ESD)treatment on the clinical efficacy and prognosis of patients with early gastrointestinal cancer.Methods Fifty patients with early gastrointestinal cancer admitted to the hospital from January 2018 to May 2020 were selected as the research objects,and were divided into control group(25 cases)and experimental group(25 cases)according to different surgical methods.The control group was treated with endoscopic mucosal resection(EMR),and the experimental group was treated with ESD.The surgical index,pain degree,surgical effect and prognosis of the two groups were compared.Results The operation time of the experimental group was(78.52±16.57)min,and the control group was(75.38±18.63)min.There was no statistically significant difference(t=0.630,P>0.05);the amount of blood loss,wound healing time,and hospital stay in the experimental group were(57.59±5.37)mL,(7.55±2.03)d,(6.40±1.48)d,the control group were(80.30±5.36)mL,(12.36±2.52)d,(11.98±1.52)d,the difference was statistically significant(t=14.970,7.430,13.150,P<0.05).The pain scores of the experimental group were(5.02±1.12)points and(2.21±0.76)points on the 1st and 3rd day after surgery,and the control group were(6.33±1.65)points and(3.32±0.87)points,the difference was statistically significant(t=3.280,4.800,P<0.05).The complete resection rate,complication rate,and recurrence rate of the experimental group were 96.00%,4.00%,4.00%,and the control group were 68.00%,32.00%,32.00%,the difference was statistically significant(χ^(2)=4.878,4.878,4.878,P<0.05).Conclusion The effect of ESD treatment in patients with early gastrointestinal cancer is more ideal,which can not only increase the complete resection rate,but also reduce pain,reduce complications and recurrence.