美托洛尔治疗慢性心衰合并心房纤颤的疗效

The Efficacy of Metoprolol in the Treatment of Chronic Heart Failure with Atrial Fibrillation

目的对慢性心力衰竭合并心房纤颤患者采用美托洛尔治疗的效果进行探究。方法选择该院收治的慢性心力衰竭合并心房纤颤患者80例作为该次研究纳入的研究对象,选取时间段为2018年6月—2019年10月,按照随机数表法将其划分为单药组和联合组,每组40例。采用胺碘酮治疗单药组患者,在此基础上,采用琥珀酸美托洛尔治疗联合组患者。对两组患者的治疗效果进行观察和比较。结果联合组总有效率(92.5%)高于单药组(77.5%),差异有统计学意义(χ^(2)=6.328,P<0.05);治疗后,联合组的左室舒张末期容积(130.5±8.1)mL、左室射血分数(42.0±4.1)%、收缩末期容积(70.1±8.2)mL等心功能指标均明显优于单药组(141.0±7.9)mL、(34.1±2.8)%、(77.6±9.5)mL,差异有统计学意义(t=5.869、10.063、3.780,P<0.05)。单药组不良反应发生率为5.0%,联合组不良反应发生率为7.5%,联合组不良反应发生率略高于单药组,但组间差异无统计学意义(χ^(2)=0.000,P>0.05)。结论针对慢性心力衰竭合并心房纤颤患者采用美托洛尔治疗效果确切,可以有效改善患者的心功能。

Objective To explore the effect of metoprolol treatment in patients with chronic heart failure and atrial fibrillation.Methods 80 patients with chronic heart failure and atrial fibrillation admitted to the hospital were selected as the subjects of this study.The selected time period was from June 2018 to October 2019,and they were divided into single drugs group and combined group according to the random number table method,each group had 40 patients.Patients in the single-agent group were treated with amiodarone,and on this basis,patients in the combined group were treated with metoprolol succinate.Observed and compared the treatment effects of the two groups of patients.Results The total effective rate(92.5%)of the combination group was higher than that of the single-drug group(77.5%),and the difference was statistically significant(χ^(2)=6.328,P<0.05);after treatment,the left ventricular end-diastolic volume of the combination group(130.5±8.1)mL,left ventricular ejection fraction(42.0±4.1)%,end-systolic volume(70.1±8.2)mL and other cardiac function indicators were significantly better than the single-drug group(141.0±7.9)mL,(34.1±2.8)%,(77.6±9.5)mL,the difference was statistically significant(t=5.869,10.063,3.780,P<0.05).The incidence of adverse reactions in the single-agent group was 5.0%,and the incidence of adverse reactions in the combined group was 7.5%.The incidence of adverse reactions in the combined group was slightly higher than that in the single-agent group,but the difference between the groups was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion Metoprolol is effective in treating patients with chronic heart failure and atrial fibrillation and can effectively improve the cardiac function of patients.