胸腹水癌细胞形态学检验的应用及临床价值评估分析

Application of Morphological Examination of Pleural and Ascites Cancer Cells and Evaluation of Clinical Value

目的探讨胸腹水癌细胞形态学检验的应用及临床价值。方法选择该院2019年1—12月收治的50例患者,对比不同的标本处理方法、标本放置时间和推片标本量对胸腹水癌细胞检出率的影响。结果第一种方法残留细胞液≥100μL高于第二种方法,第一种方法方法检出率42.00%低于第二种58.00%,差异有统计学意义(χ2=8.29,P<0.05)。2 h内离心推片情况无明显变化,4 h后离心推片核固缩、碎裂明显。加厚推片癌细胞检出率68.00%高于普通推片42.00%,差异有统计学意义(χ2=12.36,P<0.05)。结论胸腹水癌细胞形态学检验的应用价值显著,检验过程中加强标本处理、标本放置时间、涂片厚度等处理有利于提高癌细胞的检出情况,避免误诊、漏诊。胸腹水癌细胞形态学检验值得临床高度重视。

Objective To investigate the application and clinical value of morphological examination of pleural and ascites cancer cells.Methods 50 patients admitted to the hospital from January to December 2019 were selected to compare the effects of different specimen processing methods,specimen placement time,and specimen volume on the detection rate of pleural and ascites cancer cells.Results The first method had a higher residual cell fluid≥100μL than the second method,and the detection rate of the first method was 42.00%lower than that of the second method 58.00%.The difference was statistically significant(χ2=8.29,P<0.05).There was no obvious change in the centrifugal push tablet within 2 h.After 4 h,the centrifugal push tablet core had obvious shrinkage and fragmentation.The detection rate of cancer cells in the thick push film was 68.00%higher than that of the ordinary push film 42.00%.The difference was statistically significant(χ2=12.36,P<0.05).Conclusion The application value of morphological examination of cancer cells in pleural and ascites fluid is significant.Strengthening the treatment of specimens,specimen placement time,and smear thickness during the inspection process is beneficial to improve the detection of cancer cells and avoid misdiagnosis and missed diagnosis.Morphological examination of pleural and ascites cancer cells deserves clinical attention.