重复经颅磁刺激联合文拉法辛与劳拉西泮治疗广泛性焦虑研究

Repetitive Transcranial Magnetic Stimulation Combined with Venlafaxine and Lorazepam in the Treatment of Generalized Anxiety

目的研究重复经颅磁刺激(r TMS)联合文拉法辛、劳拉西泮应用到广泛性焦虑(GAD)患者中的治疗作用与效果。方法于2018年1月-2019年12月方便择选该院收治住院的202例GAD病例,参照不同的治疗方法,把其分成A组、B组,A组101例患者施予文拉法辛,B组101例患者施予r TMS联合文拉法辛、劳拉西泮,观察比较其最终的结果。结果在治疗后,对于治疗疗效,B组98例(97.03%)较A组84例(83.17%)更高,差异有统计学意义(χ^(2)=10.877,P=0.001);在治疗后,对于不良反应的总发生率,B组3例(2.97%)较A组22例(21.78%)更低,差异有统计学意义(χ^(2)=16.480,P<0.05);在治疗1周、2周、4周、6周后,对于汉密尔顿焦虑量表(HAMA)评分,B组(22.93±1.43)分、(19.56±1.23)分、(11.83±1.27)分、(5.26±1.28)分较A组(27.52±1.58)分、(24.96±1.27)分、(19.56±1.83)分、(11.09±1.56)分更低,差异有统计学意义(t=21.646、30.695、34.876、29.035,P<0.05)。结论 r TMS联合文拉法辛、劳拉西泮应用到GAD患者中,能够得到更为理想的效果。

Objective To study the therapeutic effects and effects of repeated transcranial magnetic stimulation(r TMS combined with venlafaxine and lorazepam in patients with generalized anxiety(GAD).Methods From January 2018 to December 2019,convenient select 202 GAD cases admitted to the hospital were selected and divided into groups A and B with reference to different treatment methods.101 patients in group A were given venlafaxin,101 patients in group B were given r TMS combined with venlafaxine and lorazepam to observe and compare the final results.Results After treatment,98 cases(97.03%)in group B were higher than 84 cases(83.17%)in group A,and the difference was statistically significant(χ^(2)=10.8769,P=0.001)in terms of therapeutic efficacy;the total incidence of reactions was lower in 3 cases(2.97%)in group B than 22 cases(21.78%)in group A,and the difference was statistically significant(χ^(2)=16.480,P<0.05);after treatment for 1 week,2 weeks,and 4 weeks,6 weeks later,for the Hamilton Anxiety Scale(HAMA)score,group B(22.93±1.43)points,(19.56±1.23)points,(11.83±1.27)points,(5.26±1.28)points compared with group A(27.52±1.58)points,(24.96±1.27)points,(19.56±1.83)points,(11.09±1.56)points were lower,and the difference was statistically significant(t=21.646,30.695,34.876,29.035,P<0.05).Conclusion The application of r TMS combined with venlafaxine and lorazepam to GAD patients can achieve a more ideal effect.