应用替格瑞洛联合阿司匹林治疗急性心肌梗死的效果探究

Study on the Effect of Ticagrelor Combined with Aspirin in the Treatment of Acute Myocardial Infarction

目的分析应用替格瑞洛联合阿司匹林治疗急性心肌梗死的效果。方法方便选择2018年1月-2020年1月该院急性心肌梗死患者共100例,数字表随机分两组,每组50例,对照组的患者给予阿司匹林联合氯吡格雷治疗,观察组在阿司匹林基础上增加替格瑞洛。比较两组心功能改善二级以及住院的时间、治疗前后患者心功能分级、左心室射血分数、生活质量、总有效率、不良反应。结果观察组心功能改善二级以及住院的时间(9.21±1.25)、(11.19±2.21)d短于对照组(12.56±2.21)、(15.25±3.18)d,差异有统计学意义(P<0.05)。观察组心功能分级(1.56±0.12)级低于对照组(2.34±0.45)级,左心室射血分数、生活质量(58.56±5.21)%、(93.19±5.50)分显著高于对照组(52.56±5.11)%、(80.21±5.21)分,差异有统计学意义(P<0.05)。观察组总有效率92.00%(46/50)高于对照组72.00%(36/50),差异有统计学意义(χ^(2)=6.775,P<0.05)。两组治疗过程不良反应未见。结论阿司匹林联合替格瑞洛对于急性心肌梗死的治疗效果确切。

Objective To analyze the effect of ticagrelor combined with aspirin in the treatment of acute myocardial infarction.Methods A total of 100 patients with acute myocardial infarction in our hospital from January 2018 to January2020 were conveniently selected.The number table was randomly divided into two groups of 50 cases.Patients in the control group were treated with aspirin and clopidogrel,and the observation group was based on aspirin added ticagrelor.Comparing the two groups’cardiac function improvement grade II and hospitalization time,patients’cardiac function classification before and after treatment,left ventricular ejection fraction,quality of life,total effective rate,and adverse reactions.Results The improvement of cardiac function in the observation group and the hospitalization time(9.21±1.25)d and(11.19±2.21)d were shorter than those of the control group(12.56±2.21)d and(15.25±3.18)d,the difference was statistically significant(P<0.05).The cardiac function classification(1.56±0.12)of the observation group was lower than the control group(2.34±0.45),and the left ventricular ejection fraction,quality of life(58.56±5.21)%,and(93.19±5.50)points were significantly higher than those of the control group(52.56±5.11)%,(80.21±5.21)points,the difference was statistically significant(P<0.05).The total effective rate of observation group was 92.00%(46/50)higher than that of control group72.00%(36/50),the difference was statistically significant(χ^(2)=6.775,P<0.05).There were no adverse reactions during the treatment of the two groups.Conclusion Aspirin combined with ticagrelor has a definite therapeutic effect on acute myocardial infarction.