灯盏花素联合胞磷胆碱治疗脑梗死的临床疗效探讨

The Clinical Effect of Breviscapine Combined with Citicoline in the Treatment of Cerebral Infarction

目的探讨灯盏花素联合胞磷胆碱治疗脑梗死的临床疗效。方法便利选取2018年10月-2019年12月该院收治的脑梗死患者104例为研究对象,随机数字法分为两组,对照组和研究组各52例。对照组应用常规药物治疗,研究组应用盏花素联合胞磷胆碱治疗,对比应用不同方法治疗后对两组患者NIHSS评分及临床治疗效果的影响。结果研究组治疗后,血比黏度(5.3±0.6)mPa·s、血浆黏度(1.2±0.6)mPa·s、纤维蛋白原(3.1±0.6)g/L、还原比黏度(12.5±3.9)mPa·s、红细胞积压(42.1±3.9)%各项血液流变学各项指标改善均优于对照组血比黏度(6.4±0.6)mPa·s、血浆黏度(1.6±0.5)m Pa·s、纤维蛋白原(3.6±0.4)g/L、还原比黏度(15.6±4.1)mPa·s、红细胞积压(45.7±4.4)%,差异有统计学意义(t=18.456、20.056、17.995、19.834、20.056,P<0.05);研究组治疗后NIHSS评分(7.04±2.84)分低于对照组(10.24±3.13)分,差异有统计学意义(t=21.134,P<0.05);研究组治疗有效率92.3%高于对照组80.7%,差异有统计学意义(χ^(2)=5.256,P<0.05)。结论脑梗死的治疗过程当中,灯盏花素联合胞磷胆碱的治疗效果理想,临床上应当进一步推广应用。

Objective To investigate the clinical efficacy of breviscapine combined with citicoline in the treatment of cerebral infarction.Methods A total of 104 patients with cerebral infarction admitted to the hospital from October 2018 to December 2019 were convenient selected as the research objects.The random number method was divided into two groups,with 52 cases each in the control group and the study group.The control group was treated with conventional drugs,and the study group was treated with scutellarin combined with citicoline to compare the effects of different treatment methods on the NIHSS score and clinical treatment effects of the two groups of patients.Results After treatment in the study group,blood viscosity(5.3±0.6)mPa·s,plasma viscosity(1.2±0.6)mPa·s,fibrinogen(3.1±0.6)g/L,reduction specific viscosity(12.5±3.9)mPa·s,red blood cell backlog(42.1±3.9)%improvement of various hemorheological indicators are better than the control group blood specific viscosity(6.4±0.6)mPa·s,plasma viscosity(1.6±0.5)mPa·s,Fibrinogen(3.6±0.4)g/L,reduction specific viscosity(15.6±4.1)mPa·s,red blood cell backlog(45.7±4.4)%,the difference was statistically significant(t=18.456,20.056,17.995,19.834,20.056,P<0.05);After treatment,the NIHSS score(7.04±2.84)points of the study group was lower than that of the control group(10.24±3.13)points,the difference was statistically significant(t=21.134,P<0.05);the effective rate of treatment in the study group was 92.3%higher than that of the control group by 80.7%,the difference was statistically significant(χ^(2)=5.256,P<0.05).Conclusion In the treatment of cerebral infarction,breviscapine combined with citicoline has an ideal therapeutic effect and should be further promoted and applied in clinical practice.