急性ST段抬高型心肌梗死尿激酶原溶栓后早期介入与直接介入临床效果对比

Comparison of the Clinical Effects of Early Intervention and Direct Intervention after Prourokinase Thrombolysis in Acute ST-segment Elevation Myocardial Infarction

目的对照重组人尿激酶原溶栓后早期经皮冠状动脉介入治疗(PCI)与直接PCI治疗急性ST段抬高型心肌梗死(STEMI)的临床效果。方法将该院方便选取的STEMI患者纳为研究对象,总计70例,就诊时间为2018年1月-2019年6月。依据治疗方法可分为两组,一组为行尿激酶原溶栓后早期PCI治疗的观察组(n=35),另一组为直接PCI治疗的对照组(n=35)。比较两组的造影情况及临床事件。结果观察组的血管开通率为88.57%,对照组为20.00%,组间差异有统计学意义(χ^(2)=33.158,P<0.05)。观察组的支架数量少于对照组,差异有统计学意义(t=3.982,P<0.05)。住院期间,两组的临床事件发生率比较,差异无统计学意义(P>0.05)。结论对STEMI患者采用尿激酶原溶栓后早期PCI可以提高术前血管开通率,且安全可靠,值得应用。

Objective To compare the clinical effects of early percutaneous coronary intervention(PCI)and direct PCI in the treatment of acute ST-segment elevation myocardial infarction(STEMI)after thrombolysis with recombinant human prourokinase.Methods A total of 70 cases STEMI patients selected in the hospital were conveniently selected in the study.The consultation time was from January 2018 to June 2019.According to the treatment method,it can be divided into 2 groups.One group was the observation group(n=35)for early PCI treatment after prourokinase thrombolysis,and the other was the control group for direct PCI treatment(n=35).The angiography and clinical events of the two groups were compared.Results The vascular patency rate of the observation group was 88.57%and that of the control group was 20.00%.The difference between the groups was statistically significant(χ^(2)=33.158,P<0.05).The number of stents in the observation group was less than that in the control group,and the difference was statistically significant(t=3.982,P<0.05).During hospitalization,there was no significant difference in the incidence of clinical events between the two groups(P>0.05).Conclusion Early PCI after thrombolysis with prourokinase for STEMI patients can improve the preoperative vascular opening rate,and is safe and reliable,and is worthy of application.