吗丁啉结合阿莫西林三联疗法治疗小儿功能性消化不良伴HP感染的疗效分析

Analysis of the Curative Effect of Domperidone Combined with Amoxicillin Triple Therapy on Children with Functional Dyspepsia with HP Infection

目的探讨吗丁啉结合阿莫西林三联疗法治疗小儿功能性消化不良伴幽门螺杆菌(HP)感染的临床疗效。方法方便选取2018年7月-2019年9月在该院治疗的功能性消化不良伴HP感染患儿98例,随机分为两组,每组49例。对照组给予阿莫西林三联疗法(阿莫西林+克拉霉素+雷贝拉唑)治疗,观察组在对照组基础上加用吗丁啉治疗。治疗后,比较两组临床疗效、症状评分、HP根除率。结果观察组临床治疗总有效率为93.88%(46/49),高于对照组的75.51%(37/49),差异有统计学意义(χ^(2)=6.376,P=0.012);治疗后,观察组食欲不振评分(1.41±1.10)分、餐后饱胀评分(1.60±1.31)分、腹痛评分(1.41±1.19)分、嗳气评分(1.96±1.15)分均低于对照组[(3.69±1.42)分、(3.92±1.49)分、(3.60±1.51)分、(3.53±1.28)分],差异有统计学意义(t=8.885、8.186、7.974、6.387,P<0.05);观察组HP根除率为93.88%(46/49)略高于对照组91.84%(45/49),但差异无统计学意义(χ^(2)=0.234,P=0.628)。结论吗丁啉结合阿莫西林三联疗法治疗小儿功能性消化不良伴HP感染效果确切,可改善临床症状,提高HP根除率。

Objective To investigate the clinical efficacy of domperidone combined with amoxicillin triple therapy in the treatment of children with functional dyspepsia with Helicobacter pylori(HP)infection.Methods A total of 98 children with functional dyspepsia and HP infection who were treated in the hospital from July 2018 to September 2019 were conveniently selected and randomly divided into two groups with 49 cases in each group.The control group was treated with amoxicillin triple therapy(amoxicillin+clarithromycin+rabeprazole),and the observation group was treated with domperidone on the basis of the control group.After treatment,the clinical efficacy,symptom score and HP eradication rate were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.88%(46/49),which was higher than 75.51%(37/49)in the control group.The difference was statistically significant(χ^(2)=6.376,P=0.012);after treatment,the observation group loss of appetite score(1.41±1.10)points,postprandial fullness score(1.60±1.31)points,,abdominal pain score(1.41±1.19)points,and belching score(1.96±1.15)points,were lower than the control group[(3.69±1.42)points,(3.92±1.49)points,(3.60±1.51)points,(3.53±1.28)points],the difference was statistically significant(t=8.885,8.186,7.974,6.387,P<0.05)The HP eradication rate in the observation group was 93.88%(46/49)slightly higher than 91.84%(45/49)in the control group,but the difference was not statistically significant(χ^(2)=0.234,P=0.628).Conclusion Domperidone combined with amoxicillin triple therapy is effective in the treatment of children with functional dyspepsia with HP infection,which can improve clinical symptoms and increase the eradication rate of HP.