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丙戊酸联合拉莫三嗪治疗不同类型癫痫患者的疗效及对细胞因子的影响 被引量:4

Curative effect of valproic acid combined with lamotrigine on patients with different types of epilepsy and its influence on cytokines
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摘要 目的探讨丙戊酸联合拉莫三嗪治疗不同类型癫痫患者的疗效及对细胞因子的影响。方法选择2018年10月至2019年10月孟州市人民医院收治的78例癫痫患者作为研究对象,根据癫痫类型将患者分为部分性发作组(PS组)33例、全面性发作组(GS组)26例、继发全面性发作组(SGS组)19例,利用丙戊酸联合拉莫三嗪对入组的癫痫患者进行治疗,比较3组患者治疗的有效率及细胞因子水平。结果治疗后PS组、GS组、SGS组的治疗有效率分别为79%(26/33)、88%(23/26)和79%(15/19),3组比较及组间比较差异均未见统计学意义(P>0.05)。3组在治疗后血清白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)水平均显著低于治疗前(P<0.05);治疗后3个组血清IL-6、TNF-α和IL-2水平比较差异均未见统计学意义(P>0.05)。PS组、GS组、SGS组不良反应发生率分别为6%(2/33)、8%(2/26)和5%(1/19),差异均未见统计学意义(P>0.05)。结论丙戊酸联合拉莫三嗪在不同类型的癫痫患者治疗中均取得满意成效,血清炎症因子均得到显著改善。 Objective To explore the curative effect of valproic acid combined with lamotrigine on patients with different types of epilepsy and its influence on cytokines.Methods A total of 78 patients with epilepsy in Mengzhou People’s Hospital,Jiaozhou,China from October 2018 to October 2019 were enrolled as the research objects.According to different types of epilepsy,they were divided into partial seizure(PS)group(33 cases),generalized seizure(GS)group(26 cases)and secondarily generalized seizure(SGS)group(19 cases).The patients with epilepsy were treated with valproic acid combined with lamotrigine.The response rate of treatment and levels of cytokines were compared among the three groups.Results After treatment,the response rates of treatment in PS group,GS group and SGS group were 79%(26/33),88%(23/26)and 79%(15/19),respectively.There was no significant difference among the three groups and between any two groups(P>0.05).Before and after treatment,the levels of serum interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were not significantly different(P>0.05),and there was no significant difference in the above indexes among the three groups(P>0.05).The incidence rates of adverse reactions in PS group,GS group and SGS group were 6%(2/33),8%(2/26)and 5%(1/19)respectively,and there was no significant difference among the three groups(P>0.05).Conclusion The curative effect of valproic acid combined with lamotrigine is obvious for patients with different types of epilepsy,and serum inflammatory factors are significantly improved.
作者 李大立 王献忠 杨海涛 卜祥宇 赵文凯 LI Dali;WANG Xianzhong;YANG Haitao(Department of Neurology,Mengzhou People's Hospital,Jiaozuo(454750),Henan China)
出处 《癫痫与神经电生理学杂志》 2021年第2期102-105,共4页 Journal of Epileptology and Electroneurophysiology(China)
关键词 丙戊酸 细胞因子 癫痫 拉莫三嗪 炎症因子 valproic acid cytokine epilepsy lamotrigine inflammatory factors
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