艾滋病患者行不同抗病毒方案治疗后的临床效果以及不良反应发生情况分析与研究

Analysis and Research on the Clinical Effects and Adverse Reactions of AIDS Patients Treated with Different Antiviral Regimens

目的分析艾滋病患者行不同抗病毒方案治疗后的临床效果以及不良反应发生情况。方法选择2018年1月—2020年9月传染病科的76例艾滋病患者进行了观察,采用数字法将患者分为两组,一组使用齐多夫定+拉米夫定+依非韦伦抗病毒方案治疗,作为对照组,另一组使用替诺福韦+拉米夫定+依非韦伦抗病毒治疗,作为观察组,对比两组的临床效果、不良反应和患者生活质量。结果观察组治疗后CD4+T淋巴细胞数量(672.53±83.65)个/UL,治疗3个月后转阴率是92.11%(35例),数据较之对照组差异有统计学意义(t=8.893,χ^(2)=5.604,P<0.05);观察组患者不良反应数据为13.16%(5例),对照组是47.37%(18例),组间差异有统计学意义(χ^(2)=10.536,P<0.05);观察组治疗后角色功能、社会职能、情感职能以及躯体健康评分分别是(71.4±3.4)分、(68.5±4.4)分、(70.6±3.6)分、(67.2±3.3)分,数据较之对照组更高(t=7.643、6.250、7.039、6.492,P<0.05)。结论替诺福韦+拉米夫定+依非韦伦抗病毒方案治疗艾滋病可以提高患者免疫能力,促进HIV转阴,且不良反应较少,这有助于提升患者生活质量。

Objective To analyze the clinical effects and adverse reactions of AIDS patients after different antiviral treatments.Methods In this study,a total of 76 AIDS patients in the department of infectious diseases were observed.The patients were enrolled from January 2018 to September 2020.The patients were divided into two groups using a digital method.One group used zidovudine treatment with amine+lamivudine+efavirenz as a control group,the other group was treated with tenofovir+lamivudine+efavirenz antiviral treatment,as the observation group,compared the two groups of clinical effects,adverse reactions and patient quality of life.Results The number of CD4+T lymphocytes in the observation group after treatment was(672.53±83.65)/UL,and the rate of negative conversion after three months of treatment was 92.11%(35 cases).Compared with the control group,the difference was statistically significant(t=8.893,χ^(2)=5.604,P<0.05);the adverse reaction data of patients in the observation group was 13.16%(5 cases),and the control group was 47.37%(18 cases).The difference between the groups was statistically significant(χ^(2)=10.536,P<0.05);the role function,social function,emotional function,and physical health scores of the observation group after treatment were(71.4±3.4)points,(68.5±4.4)points,(70.6±3.6)points,and(67.2±3.3)points,respectively.Compared with the control group was higher(t=7.643,6.250,7.039,6.492,P<0.05).Conclusion Tenofovir+lamivudine+efavirenz antiviral regimen can improve the immune function of patients,promote HIV to become negative,and have fewer adverse reactions,which can help improve the quality of life of patients.