中性粒细胞/淋巴细胞比值及血小板/淋巴细胞比值与视网膜静脉阻塞的相关性

Correlation Between Neutrophil to Lymphocyte Ratio,Platelet to Lymphocyte Ratio and Retinal Vein Occlusion

目的探讨中性粒细胞与淋巴细胞比值(NLR)及血小板/淋巴细胞(PLR)与视网膜静脉阻塞(RVO)的相关性以及NLR和PLR预测患者发生RVO的临床价值。方法选取2013年6月至2019年6月在河南省人民医院眼科就诊的185例RVO患者作为RVO组,并匹配同期185例年龄、性别相同的无RVO的患者作为对照组。比较两组患者的一般资料、实验室检测指标,采用多因素logistic回归分析患者发生RVO的危险因素,使用受试者工作特征(ROC)曲线评价NLR及PLR预测患者发生RVO的临床价值。结果在一般资料方面,两组性别、年龄、合并基础疾病(高血压、糖尿病、高脂血症)比较,差异无统计学意义(P>0.05)。在实验室检测指标方面,RVO组中性粒细胞(NEU)、NLR、PLR均高于对照组,淋巴细胞(LYM)低于对照组(P<0.05)。多因素logistic回归分析结果显示,NLR、PLR是RVO发生的独立危险因素(OR>1,P<0.05)。ROC曲线显示,NLR预测RVO发生的AUC为0.693(95%CI:0.643~0.739,P<0.001),灵敏度为60.00%,特异度为72.97%,最佳诊断截点为0.3297,PLR预测RVO发生的AUC为0.613(95%CI:0.561~0.663,P<0.001),灵敏度为34.14%,特异度为84.32%,最佳诊断截点为0.1946。结论较高的NLR和PLR与RVO的发生密切相关,临床上可使用NLR和PLR作为早期识别RVO风险的预测工具。

Objective To investigate the correlation between neutrophil to lymphocyte ration(NLR),platelet to lymphocyte ration(PLR)and retinal vein occlusion(RVO)and the clinical value of NLR and PLR in predicting RVO.Methods A total of 185 patients with RVO in Henan Provincial People’s Hospital from June 2013 to June 2019 were enrolled as RVO group,and 185 patients without RVO of the same age and gender during the same period were matched as control group.The general information and laboratory test indexes of the two groups were compared.Multivariate logistic regression was used to analyze the risk factors of RVO.Receiver operating characteristic(ROC)curve was used to evaluate the clinical value of NLR and PLR in predicting RVO.Results In terms of general information,there were no statistical differences in gender,age and underlying diseases(hypertension,diabetes,hyperlipidemia)between the two groups(P>0.05).In terms of laboratory test indexes,the neutrophil(NEU),NLR and PLR in RVO group were all higher than those in control group,and lymphocyte(LYM)was lower than that in control group(P<0.05).Multivariate logistic regression showed that NLR and PLR were independent risk factors for RVO(OR>1,P<0.05).ROC curve showed that area under the curve(AUC),sensitivity and specificity of NLR in predicting RVO were 0.693(95%CI:0.643 to 0.739,P<0.001),60.00%and 72.97%respectively,and optimal diagnostic cut-off point was 0.3297.AUC,sensitivity and specificity of PLR in predicting RVO was 0.613(95%CI:0.561 to 0.663,P<0.001),34.14%and 84.32%respectively,and optimal diagnostic cut-off point was 0.1946.Conclusion The higher NLR and PLR are closely related to the occurrence of RVO,and NLR and PLR can be used as predictive tools for early identification of RVO risk.