维生素D在新生儿呼吸窘迫综合征中的研究进展

Progress of vitamin D in neonatal respiratory distress syndrome

新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)是新生儿科常见急危重症,具有较高的病死率与致残率,临床上早产儿更易发生。维生素D在NRDS发生发展中有着重要的临床意义,且维生素D缺乏是其发生的独立危险因素。既往研究发现,新生儿普遍存在维生素D的缺乏或不足。维生素D可促进肺泡活性物质的合成与分泌,参与肺泡的成熟及肺血管的发育,减少新生儿呼吸窘迫综合征的发生风险。该文就维生素D在NRDS中的相关研究进行综述,以期临床重视维生素D的补充,进而为降低本病的发生风险提供参考。

Neonatal Respiratory Distress Syndrome(NRDS)is a common emergency and critical illness in neonatology,with a high mortality and morbidity rate.It is more likely to occur in premature infants.Vitamin D has an important clinical significance in the occurrence and development of NRDS,and vitamin D deficiency is an independent risk factor for its occurrence.Previous studies have found that vitamin D deficiency or insufficient was common in newborns.Vitamin D can promote the synthesis and secretion of alveolar active substances,participate in the maturation of alveoli and the development of pulmonary blood vessels,thus,reduce the risk of NRDS.This essay reviews the related researches of vitamin D in NRDS,with a view to clinically attach importance to vitamin D supplementation,so as to provide reference for reducing the risk of this disease.