正电子显像技术在肿瘤免疫治疗个体化用药中的研究进展

Advances of Research on Positron Emission Tomography in Personalized Medicine for Tumor Immunotherapy

肿瘤免疫治疗是近年来肿瘤治疗领域的重大突破,在多种恶性肿瘤中展示出显著的抗肿瘤效果。然而,临床使用提示不同患者对肿瘤免疫治疗的反应存在明显的个体差异,如何进行个体化治疗成为这类治疗的研究热点。正电子显像技术(PET)以其空间分辨率高、灵敏度高、不受内源性物质影响、定位定量准确等特点,有望在肿瘤免疫治疗个体化用药中发挥重要作用。PET可在活体无创条件下实现肿瘤免疫治疗的患者筛选、剂量优化、早期疗效预测、药效评估及安全性评价等。综述近年来PET在肿瘤免疫个体化治疗方面的研究进展,以期为肿瘤免疫类药物的研发和临床精准用药提供参考。

Tumor immunotherapy is a breakthrough in the treatment of cancer in recent years.It has shown remarkable anti-tumor effects on a variety of malignant tumors.However,clinical application has revealed significant individual differences in the response of different patients,so individualized treatment has become a research hotspot.Positron Emission Tomography(PET)imaging is expected to play an important role in personalized medicine for cancer immunotherapy due to its high spatial resolution and sensitivity,no impact from endogenous substances as well as accurate positioning and quantification.PET imaging may aid in patient screening,dose optimization,drug efficacy prediction and evaluation,and safety assessment of tumor immunotherapy under living and non-invasive conditions.This article reviews the recent research advances of PET imaging in the individualized application of tumor immunotherapy,in the hope of providing reference for the development of clinical precision medicines for tumor immunotherapy.