中药保留灌肠对子宫内膜异位症不孕患者冷冻胚胎移植妊娠结局影响的研究

Effects of Retention Enema with Traditional Chinese Medicine on Frozen Embryo Transfer in Patients with Endometriosis:A Retrospective Study

目的:观察中药保留灌肠疗法对子宫内膜异位症不孕患者冷冻胚胎移植妊娠结局的影响。方法:选取拟行冷冻胚胎移植的子宫内膜异位症患者为研究对象,共300例,分为中药保留灌肠组(n=180)和对照组(n=120),比较黄体转化日内膜厚度、生化妊娠阳性率、临床妊娠率、早期流产率及继续妊娠率。结果:中药保留灌肠组黄体转化日内膜厚度为(9.15±1.32)mm,对照组为(9.72±2.00)mm,差异无统计学意义(P>0.05);中药保留灌肠组生化妊娠阳性率为62.78%(113/180),高于对照组的51.67%(62/120),差异有统计学意义(P<0.05);中药保留灌肠组临床妊娠率为57.78%(104/180),高于对照组的50.00%(60/120),差异无统计学意义(P>0.05);中药保留灌肠组早期流产率为9.62%(10/104),低于对照组的11.67%(7/60),差异无统计学意义(P>0.05);中药保留灌肠组继续妊娠率为90.38%(94/104),高于对照组的88.33%(53/60),差异无统计学意义(P>0.05)。结论:中药保留灌肠可以改善子宫内膜异位症患者冷冻胚胎移植的妊娠结局,但仍需扩大样本量进一步证实。

Objective:To observe the effects of Traditional Chinese Medicine(TCM)retention enema in treating endometriosis(Ems)on frozen embryo transfer(FET).Methods:Totally 300 patients with EMs of FET were included,and the patients were divided into TCM retention enema group(n=180)and control group(n=120).The endometrial thickness on the day of luteal transformation,biochemical pregnancy rate,clinical pregnancy rate,early abortion rate and continued pregnancy rate were compared between the two groups.Results:The endometrial thickness on the day of luteal transformation was(9.15±1.32)mm in TCM retention enema group and(9.72±2.00)mm in control group,and there was no statistical difference on endometrial thickness on the day of luteal transformation between the two groups(P>0.05).The biochemical pregnancy rate was 62.78%(113/180)in TCM retention enema group and 51.67%(62/120)in control group;The TCM retention enema group showed higher biochemical pregnancy rate tan control group and there was statistical difference(P<0.05).The clinical pregnancy rate was 57.78%(104/180)in TCM retention enema group and 50.00%(60/120)in control group;The TCM retention enema group showed higher clinical pregnancy rate than control group,but the difference was not statistically significant(P>0.05).The early abortion rate was 9.62%(10/104)in TCM retention enema group and11.67%(7/60)in control group;The TCM retention enema group showed lower early abortion rate than control group,but there was no statistical difference(P>0.05).The ongoing pregnancy rate was 90.38%(94/104)in TCM retention enema group and 88.33%(53/60)in control group;The TCM retention enema group showed higher ongoing pregnancy rate than control group,but the difference was not statistically significant(P>0.05).Conclusions:TCM retention enema may improve the pregnancy outcome of frozen embryo transfer in patients with endometriosis,but it still needs to be further confirmed by large sample prospective studies.