脑胶质瘤的基因治疗与病毒治疗研究进展

Advances in gene therapy and viral therapy for glioma

由于脑胶质瘤肿瘤干细胞亚群的耐药性及药物难以通过血-脑屏障和脑组织免疫抑制等特点,目前的常规治疗手段并未明显提升患者的生存时间及生活质量。因此,在分子生物学进步的支持下,对脑胶质瘤新疗法的探索仍在继续。基因治疗包括将治疗用的遗传物质传送到肿瘤细胞中,从而产生特定的抗肿瘤效应。此外,因病毒具有强烈的细胞毒性作用和易于修饰,以及遗传物质水平转移的固有特性使其成为基因工程的工具。本综述介绍了多种病毒载体在胶质瘤基因治疗中的应用及溶瘤病毒疗法的研究进展。

Glioma is a highly lethal primary brain tumor.Due to the drug resistance of cancer stem cell subsets,the difficulty of drugs crossing the blood-brain barrier and immunosuppression,the conventional treatment has not significantly improved the survival time and quality of life of patients.Therefore,with the support of advances in molecular biology,the arduous exploration of new therapies continues.Gene therapy involves the delivery of therapeutic genetic material to tumor cells to produce a specific anti-tumor response.In addition,viruses are highly cytotoxic and easy to modify.The inherent characteristics of horizontal transfer of genetic material make them valuable tools for genetic engineering.This article reviews the application of various viral vectors in glioma gene therapy and oncolytic virus therapy.