中医药如何打破肿瘤细胞代谢平衡而实现“带瘤生存”的理论初探

How Does TCM Break Balance of Tumor Cell Metabolism and Realize Theory of“Tumor-Bearing Survival”

能量代谢是指有机体在物质代谢过程中能量的产生、释放、转换及利用的过程,而肿瘤细胞的异常代谢为肿瘤供能以维持肿瘤生长、转移的主要途径;故打破肿瘤异常代谢对肿瘤的治疗起着积极作用。中医药作为恶性肿瘤综合治疗措施中的一个重要组成部分,具有长期服用不良反应少、肝肾损害小、改善生活质量、抗复发和转移而呈现"带瘤生存"的特点。中医认为用"扶正抗癌"的治疗理念扶助正气,抑制异常的能量代谢,稳定瘤体可以实现"带瘤生存"的目的。文章总结了肿瘤细胞的关键代谢途径,阐明抑制肿瘤异常代谢对于肿瘤治疗的重要性,提出肿瘤细胞能量代谢的实质是"癌毒致虚",并指出打破肿瘤细胞代谢平衡当以"扶正抗癌"兼顾为主才能达到"带瘤生存"的理想状态。

Energy metabolism refers to the process of energy production,release,conversion and utilization in the process of material metabolism of an organism.Abnormal metabolism of tumor cells is the main way to maintain tumor growth and metastasis.Therefore,breaking abnormal metabolism of tumor plays an active role in the treatment of tumor.Traditional Chinese medicine(TCM),as an important part of the comprehensive treatment of malignant tumor,has the characteristics of"tumor-bearing survival",such as low toxicity and few side effects of long-term use,small liver and kidney damage,improvement of life quality,resistance to recurrence and metastasis.TCM believes that the goal of"supporting vital Qi and anti-cancer"can be achieved by supporting healthy Qi,inhibiting abnormal energy metabolism and stabilizing tumor with the therapeutic concept of"tumor-bearing survival".This paper summarized the key metabolic pathways of tumor cells,elucidated the importance of inhibiting abnormal metabolism of tumor cells for tumor treatment,proposed that the essence of energy metabolism of tumor cells was"deficiency caused by cancer toxicity",and pointed out that onlybreaking the balance of metabolism of tumor cells and focusing on"supporting vital Qi and anti-cancer"can achieve the ideal state of"tumor-bearing survival".