尼洛替尼致毛周角化病1例

A Case Report of Nilotinib-induced Keratosis Pilaris

患者男,26岁,四肢、躯干密集分布针尖至粟粒大小以毛囊为中心的褐色丘疹6个月。慢性粒细胞白血病病史1年,尼洛替尼规律治疗。组织病理表现为:表皮轻度角化过度,毛囊口扩大,可见毛囊角栓,真皮浅中层少量淋巴细胞浸润。

A 26-year-old male who had keratosis pilaris-like brown papules on the limbs and trunk for approximately six months were reported.He had significant past medical history of chronic myeloid leukaemia and treated regularly with Nilotinib for one year.Histopathological findings:mild hyperkeratosis of the epidermis,enlarged follicular orifice with follicular keratotic plugging,a few lymphocytes infiltrate from superficial to middle dermis.Diagnosis:keratosis pilaris.