益生菌复配富铬酵母缓解2型糖尿病的效果评价

Antidiabetic Effects of Probiotics Compounded with Chromium-rich Yeast Against Type 2 Diabetes

随着物质生活的不断提升,2型糖尿病患者数量在逐年上升,如何有效预防和治疗糖尿病已成为整个社会关注的焦点问题。本文将具有缓解2型糖尿病功能的鼠李糖乳杆菌CCFM0528、植物乳杆菌X1与富铬酵母进行复配,探究复配配方是否具有协同降糖作用。实验动物被随机分为5组,分别为空白组、模型组、药物组、乳酸菌组、复合组。通过喂食高脂饲料和腹腔注射链脲佐菌素STZ来诱导2型糖尿病模型。试验结果表明:造模组体重明显降低,血糖达到造模标准,建模成功。乳酸菌组和复合组血糖明显降低,其中复合组降糖效果更加明显,血脂水平和炎症水平都得到缓解,说明复合组对缓解2型糖尿病具有协同增效作用。此结果为开发安全有效的具有缓解2型糖尿病的益生菌复配产品提供了理论参考。

With the raising of the living standard,the number of patients with type 2 diabetes has increased year by year.It is an urgent issue that prevented and treated type 2 diabetes effectively.The aim of this study was to explore whether two probiotics,Lactobacillus rhamnosus CCFM0528 and L.plantarum X1,with an ability to alleviate type 2 diabetes,and chromium-rich yeast have synergistic effect on alleviating type 2 diabetes.The model of type 2 diabetes was induced by feeding high-fat diet and intraperitoneal injection of STZ.The fifty mice were divided into five groups:control groups,model group,drug group,probiotic group and cocktail groups.The results showed that the body weight of mice in the model group was significantly reduced,and the blood glucose increased dramatically and reached the modeling standard,indicating the model was established successfully.The blood glucose of the mice in probiotic group and the cocktail group were significantly reduced,while the hypoglycemic effect in the cocktail group was more obviously,the blood lipid level and inflammation level were alleviated in both probiotic group and cocktail group,the result indicating that probiotic and chromium-rich yeast have synergistic effect on alleviating type 2 diabetes.This study would provide a theoretical basis for the development of safe and effective probiotic combination products in alleviating type 2 diabetes.