泼尼松联合双嘧达莫治疗小儿肾病综合征的临床疗效及对患儿肾功能与凝血功能的影响

Clinical efficacy of prednisone combined with dipyridamole in the treatment of children with nephrotic syndrome and their effects on renal function and coagulation function

目的探讨泼尼松联合双嘧达莫治疗小儿肾病综合征(NS)的临床效果以及对患儿肾功能、凝血功能的影响。方法选取2017年1月至2020年3月本院收治的NS患儿62例,采用随机数字法分成实验组(32例)与对照组(30例)。在常规治疗的基础上,对照组患儿给予泼尼松治疗,实验组患儿给予泼尼松及双嘧达莫治疗,治疗1个月后比较两组患儿的临床治疗效果;比较两组患儿治疗前后的肾功能及凝血功能。结果实验组患儿的临床疗效明显优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的血肌酐(Scr)、尿素氮(BUN)及肌酐清除率(Ccr)水平比较,差异无统计学意义(P>0.05);治疗1个月后,两组患儿的Scr、BUN水平均显著降低并且实验组患儿的水平显著低于对照组,两组患儿Ccr水平均显著升高并且实验组患儿的水平显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)比较,差异无统计学意义(P>0.05);治疗1个月后,两组患儿的APTT、PT均显著增加,实验组患儿的APTT、PT显著大于对照组,差异有统计学意义(P<0.05)。结论泼尼松联合双嘧达莫治疗小儿NS的临床效果显著,能明显改善患儿的肾功能及凝血功能,值得推广应用。

Objective To explore the clinical effects of prednisone combined with dipyridamole in the treatment of children with nephrotic syndrome(NS)and their effects on renal function and coagulation function.Methods A total of 62 NS children admitted to our hospital from January 2017 to March 2020 were selected,and they were divided into experimental group(32 cases)and control group(30 cases)by the random number method.On the basis of conventional treatment,the control group was administrated with prednisone,whereas the experimental group was treated with prednisone and dipyridamole.After 1 month of treatment,the clinical efficacy,pre-and post-treatment renal function and blood coagulation function were compared between the two groups.Results The clinical efficacy of the experimental group was significantly superior to that of the control group,with a statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in the levels of serum creatinine(Scr),urea nitrogen(BUN)and creatinine clearance rate(Ccr)between the two groups(P>0.05).After 1 month of treatment,the levels of Scr and BUN significantly decreased,whereas Ccr level significantly increased in both groups;as compared with the control group,the experimental group yielded lower levels of Scr and BUN,while a higher level of Ccr,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in the activated partial thromboplastin time(APTT)and prothrombin time(PT)between the two groups(P>0.05).After 1 month of treatment,the APTT and PT increased significantly in both groups,the indicators mentioned above of the experimental group were significantly greater than those of the control group,with statistically significant differences(P<0.05).Conclusion The clinical effect of prednisone combined with dipyridamole in the treatment of NS children is prominent,and it can significantly improve the renal function and blood coagulation function in children,which is worthy of promotion and application.