排石颗粒辅助治疗肾结石的疗效及对患者抗炎镇痛的影响

The effect of Paishi granule in adjuvant treatment of renalcalculi and its effect on anti inflammation and analgesia

目的研究排石颗粒辅助治疗肾结石的疗效及对患者抗炎镇痛的影响。方法选取2016年7月至2019年6月本院收治的肾结石患者280例,按随机数字表法分为排石颗粒组与对照组,各140例。对照组在基础治疗、体外冲击波碎石术(ESWL)治疗基础上给予盐酸坦索罗辛缓释胶囊治疗,排石颗粒组在对照组基础上给予排石颗粒治疗。观察比较两组碎石成功、结石排出时间、结石排净情况、肾绞痛发生情况及程度、血尿持续时间及治疗前后CRP(C-反应蛋白)、IL-6(白介素-6)、IL-8(白介素-8)等指标。结果排石颗粒组碎石成功率(97.86%)与对照组(97.14%)比较差异无统计学意义。排石颗粒组结石排净率(75.00%)高于对照组(52.14%),肾绞痛发生率(7.86%)低于对照组(27.86%)(P<0.05)。排石颗粒组结石排出时间、血尿持续时间均短于对照组,肾绞痛VAS评分低于对照组(P<0.05)。治疗后,排石颗粒组CRP、IL-8低于对照组,IL-6水平均显著高于对照组(P<0.05)。结论排石颗粒辅助治疗肾结石可有效促进ESWL术后结石排出,抗炎消痛,降低感染率。

Objective To study the effect of Paishi Granule on the treatment of renal calculi and its effect on the patients'anti-inflammatory and analgesic effects.Methods 280 patients with renal calculi admitted to our hospital from July 2016 to June 2019 were divided into Paishi granule group and control group according to the random number table method,with 140 cases in each group.The control group was treated with tamsulosin hydrochloride sustained-release capsule on the basis of basic treatment and extracorporeal shock wave lithotripsy(ESWL).The Paishi granule group was treated with Paishi Granule on the basis of the control group.The success rate of lithotripsy,stone discharge time,stone clearance,occurrence and degree of renal colic,duration of hematuria,CRP(C-reactive protein),IL-6(interleukin-6),IL-8(interleukin-8)before and after treatment were observed and compared between the two groups.Results There was no significant difference between the Paishi granule group(97.86%)and the control group(97.14%).The stone removal rate of Paishi granule group(75.00%)was higher than that of the control group(52.14%),and the incidence of renal colic(7.86%)was lower than that of the control group(27.86%)(P<0.05).The time of stone excretion,VAS score of renal colic and duration of hematuria in Paishi granule group were lower than those in the control group(P<0.05).The CRP and IL-8 in the treatment group were lower than those in the control group,and the IL-6 water was significantly higher than that in the control group.Conclusion Paishi granules in the adjuvant treatment of kidney stones can effectively promote stone discharge after ESWL,anti-inflammatory and pain-relieving,and reduce infection rate.