Notch受体家族与心肌重构的研究进展

Research progress of Notch receptor family and myocardial remodeling

心肌重构是多种心脏疾病的关键病理生理过程,寻找有效的干预措施具有重要的科学意义。Notch受体家族是一种高度保守的膜蛋白受体家族,广泛表达于心脏组织,研究证明Notch家族各个成员可通过抗氧化、抗凋亡、抗纤维化及促血管生成等不同方式参与心肌重构的发生发展,研究其具体作用及机制可为心肌重构的治疗提供方向。文章对Notch受体家族与心肌重构的研究进展进行综述。

Myocardial remodeling is a key pathophysiological process of a variety of heart diseases,and finding effective interventions has important scientific significance.The Notch receptor family is a highly conserved membrane protein receptor family,which is widely expressed in heart tissue.Studies have shown that each member of the Notch family can participate in myocardial remodeling in different ways such as anti-oxidation,anti-apoptosis,anti-fibrosis and promoting angiogenesis.The occurrence and development of myocardial structure,the study of its specific effects and mechanisms can provide directions for the treatment of myocardial remodeling.This article reviews the research progress of Notch receptor family and myocardial remodeling.