脑容积的影响因素及其临床意义研究进展

Research Progress of Influencing Factors of Brain Volume and Its Clinical Significance

早在多年前就有学者关注脑容积的测量,但仅限于科研领域,其几乎不应用于临床工作,也可能限于影像学发展水平,既往相关研究结果的准确度有限。笔者通过检索及总结国内外相关文献,指出脑容积的影响因素有很多,包括吸烟、社会经济地位(SES)、体质指数、血管危险因素负担、视网膜外层参数等,且其与多种疾病的发生发展有关,如多发性硬化症(MS)、脑卒中、急性缺血性脑卒中(AIS)、阿尔茨海默病(AD)、轻度认知障碍(MCI)等,其可能可用于这些疾病的诊断、治疗及预后评估。

As early as many years ago,scholars have paid attention to the measurement of brain volume,but it is limited to the field of scientific research,it is hardly applied to clinical work,or may be limited to the level of imaging development,and the accuracy of previous related research results is limited.Through searching and summarizing relevant domestic and foreign literatures,the author points out that there are many factors affecting brain volume,including smoking,socioeconomic status(SES),body mass index,burden of vascular risk factors,outer retinal parameters,etc.And it is related to the occurrence and development of many diseases,such as multiple sclerosis(MS),stroke,acute ischemic stroke(AIS),Alzheimer’s disease(AD),mild cognitive impairment(MCI),etc.,which may be used in the diagnosis,treatment and prognosis evaluation of these diseases.