支架内新生动脉粥样硬化与不同免疫反应及免疫细胞关系的研究进展

Research progress of relationship among different immune responses,immune cells and in-stent neo-atherosclerosis

支架置入术后,支架内再狭窄(ISR)及晚期血栓形成仍为影响PCI术疗效的重要因素。近年来大量证据表明:支架内新生动脉粥样硬化(ISNA)发生发展过程与原发性动脉粥样硬化大致相同,都具有慢性炎症的特征。免疫炎症类型及相关分子机制是ISNA斑块中的免疫炎症基础。本文就ISNA与不同免疫类型及免疫细胞的关系作一综述,旨在为了解ISNA的发生发展过程提供新思路。

After stent implantation,in-stent restenosis(ISR)and late thrombosis are still important factors affecting therapeutic effect of PCI.In recent years,a large amount of evidence suggest that occurrence and development process of in-stent neo-atherosclerosis(ISNA)is roughly the same as that of primary atherosclerosis,and both have the characteristics of chronic inflammation.Types of immune inflammation and related molecular mechanisms are the basis of immune inflammation in ISNA plaques.The present article made a review on the relationship among different immune types,immune cells and ISNA,aiming at providing new thinking for understanding the occurrence and development of ISNA.