基于文献计量学和可视化技术分析地舒单抗及双膦酸盐治疗骨质疏松性骨折的研究现状及趋势

Research status and future trends of bibliometrics and visualization technology for Xgeva and bisphosphonates in the treatment of osteoporotic fracture

目的:随着老龄化进程加速,骨质疏松性骨折(osteoporotic fracture, OPF)的研究越来越受到人们的关注。本研究的目的是研究全球地舒单抗、双膦酸盐治疗OPF的现状和趋势。方法:检索1994-2018年双膦酸盐和OPF相关文献,检索自Science Citation·Index-Expanded Web of Science(科学引文索引-扩展科学网)。利用文献计量学方法对来源数据进行研究和索引。为了进行可视化研究,使用VOS viewer软件进行书目关联、共著和共现分析,并分析用于OPF研究的发表趋势。结果:共纳入文献3 879篇。相关研究的热点和出版物的数量每年都在不断增加。美国对全球研究的贡献率最高。国际骨质疏松杂志和BONE期刊发表率最高。谢菲尔德大学、加州大学旧金山分校和列日大学是最有贡献的机构,地舒单抗则是安进公司和哥伦比亚大学。研究方向主要为内分泌代谢研究、药理学研究和临床研究三大类。在这一领域临床研究仍然是热门话题。结论:根据目前的趋势,关于OPF的出版物数量将会增加。美国是该领域最大的贡献者。最新药物研究热度:地舒单抗>阿仑膦酸钠>唑来膦酸钠>利塞膦酸钠>伊班膦酸钠,地舒单抗在OPF中的应用可能是药物研究未来的热点,随着临床应用推广,中国在此研究领域潜力巨大。

OBJECTIVE To explore current status and future trend in the emerging field of osteoporotic fracture(OPF).METHODS The relevant literatures of OPF were retrieved from Science Citation Index-Expanded Web of Science from 1994 to 2018.Bisphosphonates were employed for collating the source data.For visualizing the OPF researches, VOS viewer software was utilized for analyzing bibliographic association, co-authorship, co-occurrence and publishing trends.RESULTS A total of 3,879 reports were included.The numbers of publications and research hotspots were rising annually.The United States had the highest contribution rate to global researches.Osteoarthritis and cartilage periodicals showed the highest publishing rate.University of Sheffield, University of California, San Francisco and University of Liege were the most productive institutions.Research fell into four categories of mechanism, animal, clinical trial and tissue engineering.Clinical research in this field was expected to be the next hot topic.CONCLUSION According to current trends, the number of OPF publications shall continuously increase.Application of bisphosphonates is probably a hot topic in OPF and drug developments.