卡托普利联合肝素钠对肾病综合征患者肾功能及血液流变学指标的影响

Effects of Captopril Combined with Heparin on Renal Function and Hemorheology in Patients with Nephrotic Syndrome

目的:探讨卡托普利联合肝素钠对肾病综合征患者肾功能及血液流变学指标的影响。方法:选取2018年4月-2020年3月本院收治的肾病综合征患者92例作为研究对象,用信封法将患者分为对照组和研究组,各46例。对照组采用常规治疗,研究组采用卡托普利联合肝素钠治疗。对比两组患者的血浆白蛋白、24 h尿蛋白量及血尿素氮、血脂指标、肾功能指标、血液流变学指标和临床治疗效果。结果:治疗后,研究组的血浆白蛋白水平高于对照组、24 h尿蛋白定量低于对照组,差异均有统计学意义(P<0.05);研究组总有效率为87.0%,高于对照组的60.9%,差异有统计学意义(P<0.05);治疗后,研究组的HDL-C水平高于对照组,TC、TG、LDL-C水平均低于对照组(P<0.05);治疗后,研究组Scr及BUN水平均低于对照组,差异均有统计学意义(P<0.05);治疗后,研究组纤维蛋白原、全血黏度高切及低切、血浆黏度、D-二聚体水平均低于对照组(P<0.05)。结论:卡托普利联合肝素钠治疗肾病综合征,可有效改善患者白蛋白、24 h尿蛋白定量,降低肾功能指标水平,还能调节血脂,改善患者血液流变学指标水平,提高治疗效果,临床可推广应用。

Objective:To investigate the effects of Captopril combined with Heparin Sodium on renal function and hemorheology in patients with nephrotic syndrome.Method:A total of 92 patients with nephrotic syndrome admitted to our hospital from April 2018 to March 2020 were selected as the research subjects,and the patients were divided into control group and research group by envelope method,with 46 cases in each group.The control group was treated by routine treatment,and the study group was treated by Captopril combined with Heparin Sodium.The levels of plasma albumin,24 h urinary protein,blood urea nitrogen,blood lipid,renal function,hemorheology and clinical treatment were compared between the two groups.Result:After treatment,the plasma albumin level of the study group was higher than that of the control group,and 24 h urinary protein group was lower than that of the control group,the differences were statistically significant (P<0.05).The total effective rate of the study group was 87.0%,higher than 60.9% of the control group,the difference was statistically significant (P<0.05).After treatment,the level of HDL-C in the study group was higher than that in the control group,and the levels of TC,TG and LDL-C were lower than those in the control group (P<0.05).After treatment,Scr and BUN levels in the study group were lower than those in the control group,with statistical significance (P<0.05).After treatment,the levels of fibrinogen,high and low blood viscosity,plasma viscosity and D-dimer in the study group were all lower than those in the control group (P<0.05).Conclusion:Captopril combined with Heparin Sodium in the treatment of nephrotic syndrome can effectively improve the amount of albumin 24 h urinary protein in patients,reduce the level of renal function indexes,regulate blood lipid,improve the level of hemorheology indexes in patients,and improve the therapeutic effect,it can be popularized and applied in clinical practice.