胱抑素C与急性心肌梗死的研究进展

Research Progress of Cystatin C and Acute Myocardial Infarction

胱抑素C是一种半胱氨酸蛋白酶抑制剂,是人胱抑素2型超家族的成员,可促进冠状动脉粥样硬化的过程,并且与急性心肌梗死的发生发展以及预后存在着密切关系,是心血管疾病方面独立的危险因素。诊断急性心肌梗死的特异性生物标记物主要为心肌特有的肌钙蛋白I等,其升高往往在心肌已经发生坏死之后,具有明显的延迟性。因此,越来越多的学者在积极寻找能够早期识别急性心肌梗死的生物标记物,实现对高危患者的早期干预和精准管理。本文综合最新的文献结果,就胱抑素C生物特性、致病机制及其与急性心肌梗死的关系等方面予以综述。

Cystatin C is a cysteine protease inhibitor,a member of the cystatin type 2 superfamily,which can promotes the process of coronary atherosclerosis and is closely associated with the development and prognosis of acute myocardial infarction.It is an independent risk factor for cardiovascular disease.The specific biomarkers for the diagnosis of acute myocardial infarction are mainly troponin I,which is specific to the myocardium and has obvious delay.Therefore,more and more scholars are actively looking for biomarkers that can identify acute myocardial infarction in the early stage,so as to realize early intervention and accurate management of high-risk patients.Based on the latest literature,this paper reviews the biological characteristics of cystatin C,its pathogenesis and its relationship with acute myocardial infarction.