血清淀粉样蛋白A、超敏C反应蛋白联合检测对脓毒症患儿感染类型及病情严重程度的诊断价值

Analysis of the diagnostic value of combined detection of serum myloid A and high sensitivity C-reactive protein in the type of infection and severity of sepsis in children

目的:探讨血清淀粉样蛋白A(SAA)、超敏C反应蛋白(hs-CRP)联合检测对脓毒症患儿感染类型及病情严重程度的诊断价值。方法:根据感染类型将300例脓毒症患儿分为细菌感染组(n=138)和病毒感染组(n=162),根据病情严重程度分为一般脓毒症组(n=159)和重度脓毒症组(n=141)。采用胶乳增强免疫比浊法测定SAA和hs-CRP水平,采用受试者工作特征曲线(ROC)分析SAA联合hs-CRP对脓毒症患儿感染类型及病情严重程度的诊断价值。结果:细菌感染组SAA、hs-CRP水平均高于病毒感染组(P<0.05);重度脓毒症组SAA、hs-CRP水平均高于一般脓毒症组(P<0.05)。ROC曲线分析显示,以SAA联合hs-CRP诊断脓毒症患儿感染类型的曲线下面积为0.973,敏感度为90.28%,特异度为93.59%;以SAA联合hs-CRP诊断脓毒症患儿病情严重程度的曲线下面积为0.976,敏感度为93.08%,特异度为92.20%。结论:SAA联合hs-CRP检测对脓毒症患儿感染类型及病情严重程度具有重要的诊断价值。

Objective:To explore the diagnostic value of combined detection of serum amyloid A(SAA)and high sensitivity C-reactive protein(hs-CRP)in the type of infection and severity of sepsis in children.Methods:A total of 300 children with sepsis treated were selected.According to the type of infection,the children were divided into bacterial infection group(n=138)and virus infection group(n=162),and were subdivided into general sepsis group(n=159)and severe sepsis group(n=141)according to the severity of the disease.The levels of SAA and hs-CRP were measured by latex enhanced immunoturbidimetry,and the diagnostic value of SAA combined with hs-CRP in the diagnosis of infection type and severity of sepsis was analyzed by receiver operating characteristic curve(ROC).Results:The levels of SAA and hs-CRP in bacterial infection group were significantly higher than those in virus infection group(P<0.05).The levels of SAA and hs-CRP in severe sepsis group were significantly higher than those in general sepsis group(P<0.05).ROC curve analysis showed that SAA combined with hs-CRP in the diagnosis of infection in children with sepsis had the largest area under the curve(0.973),the sensitivity was 90.28%,and the specificity was 93.59%.SAA combined with hs-CRP in diagnosing the severity of sepsis had the largest area under the curve of 0.976,the sensitivity was 93.08%,and the specificity was 92.20%.Conclusion:SAA combined with hs-CRP plays an important role in the diagnosis of infection type and severity of sepsis in children.