血清PGⅠ、PGⅡ及G17水平诊断十二指肠溃疡的价值及其与Hp感染、病情的相关性

The value of serum PGⅠ,PGⅡ,G17 in the diagnosis of duodenal ulcer and their correlation with Hp infection and disease condition

目的:探究血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及胃泌素17(G17)水平诊断十二指肠溃疡的价值及与Hp感染、病情的相关性。方法:分别选择95例十二指肠溃疡患者和52名健康受试者分别作为观察组和对照组,测定血清PGⅠ、PGⅡ及G17水平,收集十二指肠溃疡患者胃镜检查资料及幽门螺旋杆菌感染(Hp)资料。结果:十二指肠溃疡患者血清PGⅠ、PGⅡ及G17水平均高于对照组(P<0.05);血清PGⅠ、PGⅡ及G17诊断十二指肠溃疡的曲线下面积分别为0.841、0.882和0.889,当其截点值为132.1μmol/L、15.45μmol/L、16.25 pmol/L时,约登指数最大;PGⅠ+PGⅡ、PGⅠ+G17、PGⅡ+G17的接受者操作特性(ROC)曲线下面积分别为0.901、0.892、0.912和0.913。十二指肠溃疡Hp阳性患者血清PGⅠ、PGⅡ及G17水平高于十二指肠溃疡Hp阴性患者(P<0.05);溃疡面积>1.0 cm十二指肠溃疡患者血清PGⅠ、PGⅡ及G17水平高于面积<1.0 cm十二指肠溃疡患者(P<0.05);Pearson相关性分析示,血清PGⅠ、PGⅡ及G17水平与溃疡面积呈正相关(P<0.05)。结论:十二指肠溃疡患者伴有血清PGⅠ、PGⅡ及G17水平的升高,其水平与Hp感染及病情密切相关,可用于临床诊断及病情评估。

Objective:To investigate the value of serum pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and gastrin 17(G17)in the diagnosis of duodenal ulcer and their correlation with helicobacter pylori(Hp)infection and the condition of disease.Methods:95 patients with duodenal ulcer and 52 healthy subjects were respectively selected as the observation group and control group.The levels of serum PGⅠ,PGⅡand G17 were measured.The data of gastroscopy and Hp infection in patients with intestinal ulcer were also collected.Results:The levels of serum PGⅠ,PGⅡand G17 in patients with duodenal ulcer were significantly higher than those in the control group(P<0.05).The areas under the curve of serum PGⅠ,PGⅡand G17 for the diagnosis of duodenal ulcer were 0.841,0.882 and 0.889,respectively.When the cut-off values were 132.1μmol/L,15.45μmol/L and 16.25 pmol/L,the Youden index was the largest.The areas under the receiver operating characteristic(ROC)curve of PGⅠ+PGⅡ,PGⅠ+G17 and PGⅡ+G17 respectively were 0.901,0.892,0.912 and 0.913.The levels of serum PGⅠ,PGⅡand G17 in patients with Hp positive duodenal ulcer were significantly higher than those with Hp negative duodenal ulcer(P<0.05).The levels of serum PGⅠ,PGⅡand G17 in patients with duodenal ulcer with area>1.0 cm were obviously higher than those with duodenal ulcer with area<1.0 cm(P<0.05).Pearson correlation analysis showed that the levels of serum PGⅠ,PGⅡand G17 were positively correlated with ulcer area(P<0.05).Conclusion:Patients with duodenal ulcers are accompanied by elevated serum PGⅠ,PGⅡand G17 levels,which are closely related to Hp infection and the condition of disease.Clinically,they can be used for clinical diagnosis and disease evaluation of duodenal ulcers.