神经内分泌轴与阿尔茨海默病的研究进展

Research Progress of Neuroendocrine Axis and Alzheimer’s Disease

阿尔茨海默病(AD)是常见的进行性大脑神经退行性疾病,同时也是导致痴呆的主要原因,而且AD患病率持续增长。AD的病理特点是脑内β淀粉样蛋白(Aβ)聚集和tau蛋白过度磷酸化,致记忆减退和认知损害,最终导致神经退行性变。激素是大脑发育的主要生理调节因子之一,内分泌系统功能障碍可能导致AD发生,研究表明部分神经内分泌轴参与AD的发病及进展。文中对神经内分泌轴与AD相关的研究进行综述。

Alzheimer’s disease(AD)is a common progressive neurodegenerative disease of the brain and a leading cause of dementia,and the prevalence of AD continues to increase.AD is pathologically characterized by accumulation ofβ-amyloid(Aβ)in the brain and hyperphosphorylation of tau protein,which leads to impaired memory and a variety of cognitive abilities,and ultimately leads to neurodegenerative changes.Hormone is one of the main physiological regulators of brain development,Endocrine system dysfunction may lead to AD,and studies have shown that part of the neuroendocrine axis is involved in the etiology and progression of AD.The research on neuroendocrine axis and AD was reviewed.