FOXO1影响胰岛β细胞去分化作用机制研究

Study on the Mechanism of FOXO1 Affecting the Dedifferentiation of Islet β Cells

β细胞的功能缺陷是我国2型糖尿病的主要的发病机制之一。近年来大量研究表明β细胞去分化是β细胞功能缺陷的主要原因,而FOXO1是对β细胞的去分化有着重要影响的核转录因子,这方面的研究可以为糖尿病的治疗和研究提供新的思路和方向。本文针对FOXO1影响β细胞去分化的作用机制,以及能够抑制和逆转β细胞去分化的干预措施做了系统的总结和分析,发现减肥和饮食控制,以及早期使用胰岛素被证明可以有效抑制和逆转β细胞去分化,其他药物在此方面的作用尚需要进一步证实。

The functional defect of β cells is one of the main pathogenesis of type 2 diabetes in China. A large number of studies in recent years have shown that β-cell dedifferentiation is the main cause of β-cell dysfunction, and FOXO1 is a nuclear transcription factor that has an important influence on β-cell dedifferentiation. Studies in this area can provide new ideas and directions for the treatment and research of diabetes. This article systematically summarizes and analyzes the mechanism of FOXO1’s effect on β-cell dedifferentiation and interventions that can inhibit and reverse β-cell dedifferentiation. It is found that weight loss and diet control, and early use of insulin have been shown to effectively inhibit and reverse β-cell dedifferentiation, the role of other drugs in this area needs to be further confirmed.