喹硫平联合碳酸锂对双相情感障碍躁狂发作患者躁狂程度及炎症指标的影响

Effects of Quetiapine Combined with Lithium Carbonate on Manic Degree and Inflammation Indexes in Patients with Bipolar Disorder Manic Episode

目的:探究喹硫平联合碳酸锂对双相情感障碍躁狂发作患者躁狂程度及炎症指标的影响。方法:回顾性分析2018年7月—2020年1月洛阳市第五人民医院收治的80例双相情感障碍躁狂发作患者临床资料,根据治疗方案不同进行分组,将40例使用碳酸锂治疗的患者纳入对照组,将40例使用喹硫平联合碳酸锂治疗的患者纳入观察组,两组均治疗2周。比较两组治疗前、治疗2周后贝克-拉范森躁狂量表(BRMS)评分、简易智力状态检查量表(MMSE)评分及炎症指标[白介素-1β(IL-1β)、白介素-4 (IL-4)、白介素-10 (IL-10)、肿瘤坏死因子-α(TNF-α)]。结果:治疗前,两组BRMS、MMSE评分、IL-1β、IL-4、IL-10、TNF-α对比,差异无统计学意义(P>0.05);治疗2周后,两组BRMS评分、IL-1β、TNF-α均降低,MMSE评分、IL-4、IL-10均升高,且观察组变化幅度比对照组大,差异有统计学意义(P<0.05)。结论:双相情感障碍躁狂发作患者给予喹硫平联合碳酸锂治疗可以降低患者狂躁程度,提升患者认知能力,改善炎症因子水平,促进患者康复。

Objective:To explore the effect of quetiapine combined with lithium carbonate on the degree of mania and inflammation in patients with bipolar disorder manic episode.Methods:The clinical data of 80 patients with manic episodes of bipolar disorder who were admitted to the hospital from July 2018 to January 2020 were retrospectively analyzed.They were grouped according to different treatment plans.40 patients treated with lithium carbonate were included in the control group and 40 patients treated with quetiapine combined with lithium carbonate were included in the observation group,and both groups were treated for 2 weeks.Before and after treatment,Baker-Lavanson Mania Scale(BRMS)score,Mini-Mental State Examination Scale(MMSE)score and inflammation indicators[Interleukin-1β(IL-1β),Interleukin-4(IL-4),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)]of the two groups were compared.Results:Before treatment,there was no statistically significant difference in BRMS,MMSE score,IL-1β,IL-4,IL-10,and TNF-αbetween the two groups(P>0.05).After 2 weeks of treatment,the BRMS score and IL-1βand TNF-αof the two groups all decreased,MMSE score,IL-4 and IL-10 all increased,and the change range of the observation group was larger than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The treatment of quetiapine combined with lithium carbonate in patients with bipolar disorder manic episode can reduce the manic degree of the patient,improve the patient’s cognitive ability,improve the level of inflammatory factors,and promote the patient’s recovery.