血塞通注射液联合复方甘草酸苷治疗儿童过敏性紫癜性肾炎疗效及安全性评价

Evaluation on Curative Efficacy of Sanqi Panaxnotoginseng Injection Combined with Compound Glycyrrhizin in the Treatment of Child Allergic Purpura Nephritis

目的:观察血塞通注射液联合复方甘草酸苷治疗儿童过敏性紫癜性肾炎疗效及安全性。方法:73例儿童过敏性紫癜性肾炎患者按照随机数字表法将其随机分为对照组和治疗组。对照组37例,予复方甘草酸苷注射液20~60 ml,每日1次;治疗组36例,在对照组基础上加用血塞通注射液4~8 mg/kg,每日1次。结果:4周后,治疗组有效率为94.44%优于对照组的70.27%(P<0.05);治疗组血浆黏度(PV)降低,凝血酶原时间(PT)延长,两组比较,差异有统计学意义(P<0.05);尿隐血(BLD)、尿蛋白(PRO)及尿β2-微球蛋白(β2-MG)转阴率比较,治疗组明显高于对照组(P<0.05)。结论:血塞通注射液联合复方甘草酸苷治疗过敏性紫癜性肾炎疗效好,安全性高。

Objective:To evaluate the efficacy and safety of sanqi panax notoginseng injection combined with compound glycyrrhizin for the treatment of child with allergic purpura nephritis.Methods:73 children with allergic purpura nephritis were divided randomly into the treatment group(n=36)and the control group(n=37).Compound glycyrrhizin were used for the control group,at the same time,sanqi panax notoginseng injection and compound glycyrrhizin were used for the treatment group.Results:After treatment,the total efficiency rate in the treatment group(94.44%)was higher than that in the control group(70.27%).Compared with the control group,plasma viscosity and prothrombin time in the treatment group displayed significant improvement.The turning negative rate of BLD,PRO andβ2-MG of the treatment gruop was higher than those of the control group(P<0.05).Conclusion:There is good therapy effect and high safety degree of treating child allergic purpura nephritis with Sanqi Panaxnotoginseng injection and compound glycyrrhizin,which deserves further development.