布地奈德福莫特罗联合肺康复训练对基层中重度慢阻肺患者稳定期肺功能以及生活质量改善情况的效果观察

Effect of Budesonide Fomoterol combined with pulmonary rehabilitation training on pulmonary function and improvement of quality of life in patients with moderate-severe chronic obstructive pulmonary disease in stable phase

目的探讨布地奈德福莫特罗联合肺康复训练对基层中重度慢性阻塞性肺疾病(COPD)患者稳定期肺功能以及生活质量的影响。方法选取2017年7月~2019年12月于赣州市南康区第二人民医院就诊的86例中重度COPD患者为研究对象,按随机数字表法分为对照组(43例)和观察组(43例)。对照组采用布地奈德福莫特罗治疗,观察组在对照组基础上加用肺康复训练治疗。比较两组用力肺活量(FVC)、第1秒用力呼气量(FEV1)、6 min步行试验距离、生活质量评分及急性发作率。结果治疗后观察组FVC为(2.89±0.41)L、FEV1为(2.03±0.35)L,高于对照组的(2.57±0.38)、(1.81±0.31)L,差异有统计学意义(P<0.05)。治疗后观察组6 min步行试验距离为(364.78±25.65)m,长于对照组的(324.14±23.59)m,差异有统计学意义(P<0.05)。治疗后观察组COPD评估测试(CAT)评分为(14.39±2.42)分、改良英国医学研究会呼吸困难指数(mMRC)为(1.59±0.22)分,低于对照组的(18.93±2.56)、(1.81±0.25)分,差异有统计学意义(P<0.05)。观察组急性发作率为4.65%,低于对照组的18.60%,差异有统计学意义(P<0.05)。结论布地奈德福莫特罗联合肺康复训练可增强中重度慢性阻塞性肺疾病患者肺功能,减少急性发作次数,改善生活质量。

Objective To investigate the effect of Budesonide Formoterol combined with pulmonary rehabilitation training on lung function and quality of life in moderate to severe chronic obstructive pulmonary disease(COPD)patients at stable stage.Methods A total of 86 patients with moderate and severe COPD who were treated in the Second People′s Hospital of Nankang District in Ganzhou City from July 2017 to December 2019 were selected as the research subjects.According to random number table method,they were divided into control group(43 cases)and observation group(43 cases).The control group was treated with Budesonide Formoterol,and the observation group was treated with pulmonary rehabilitation training on the basis of the control group.Forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),6-min walking distance,quality of life score and acute attack rate were compared between the two groups.Results After treatment,the FVC and FEV1 of the observation group were(2.89±0.41)and(2.03±0.35)L,which were higher than those of the control group(2.57±0.38)and(1.81±0.31)L,the differences were statistically significant(P<0.05).After treatment,the 6 min walking distance of the observation group was(364.78±25.65)m,longer than that of the control group of(324.14±23.59)m,and the difference was statistically significant(P<0.05).After treatment,COPD assessment test(CAT)score and modified British medical research council dyspnea index(mMRC)score in the observation group were(14.39±2.42)and(1.59±0.22)points,lower than those in the control group of(18.93±2.56) and (1.81±0.25) points, the differences were statistically significant (P<0.05). The acute attack rate of the observation group was 4.65%, lower than that of the control group (18.60%), the difference was statistically significant (P<0.05). Conclusion Budesonide Formoterol combined with pulmonary rehabilitation training can enhance lung function, reduce the number of acute attacks and improve the quality of life in patients with moderate to severe COPD.