枸地氯雷他定联合丙酸氟替卡松治疗神经性皮炎的临床效果

Clinical effect of Loratadine Citrate combined with Fluticasone Propionate in the treatment of neurodermatitis

目的探讨枸地氯雷他定联合丙酸氟替卡松治疗神经性皮炎的临床效果。方法选取辽宁省健康产业集团铁煤总医院2018年12月~2019年12月收治的96例神经性皮炎患者作为研究对象,按照奇偶数分组法分为观察组(n=48)与对照组(n=48)。对照组采用丙酸氟替卡松治疗,观察组采用枸地氯雷他定联合丙酸氟替卡松治疗,连续治疗2周。比较两组的临床效果以及治疗前后靶皮损面积和皮损程度评分、皮肤瘙痒评分和湿疹病情指数评分。结果观察组患者的临床总有效率高于对照组,差异有统计学意义(P<0.05);治疗后两组患者的靶皮损面积、皮损程度评分、皮肤瘙痒评分、湿疹病情指数评分均低于治疗前,差异有统计学意义(P<0.05);治疗后观察组患者的靶皮损面积、皮损程度评分、皮肤瘙痒评分、湿疹病情指数评分均低于对照组,差异有统计学意义(P<0.05)。结论枸地氯雷他定联合丙酸氟替卡松能够明显减轻神经性皮炎患者的瘙痒感和湿疹情况,明显改善患者的皮损程度,应用价值较高。

Objective To explore the effective effect of Loratadine Citrate combined with Fluticasone Propionate in the treatment of neurodermatitis.Methods A total of 96 patients with neurodermatitis admitted to Iron Coal General Hospital of Liaoning Health Industry Group from December 2018 to December 2019 were selected as research object.They were divided into an observation group(n=48)and a control group(n=48)by odd-even grouping.The control group was treated with Fluticasone Propionate,and the observation group was treated with Loratadine citrate combined with Fluticasone Propionate.The clinical effect of the two groups and the target skin lesion area and skin lesion score before and after treatment,skin itching score and eczema condition index score were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that in the control group,the difference was statistically significant(P<0.05);After treatment,the target skin lesion area,skin lesion degree score,skin itching score and eczema condition index score of the two groups of patients were lower than those before treatment,and the differences were statistically significant(P<0.05);the target skin lesion area,skin lesion degree score,skin itching score and eczema condition index score of the two groups of patients were all lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion Patients with neurodermatitis treated with Loratadine Citrate combined with Fluticasone Propionate can significantly reduce the itchiness and eczema of the patient,significantly improve the degree of skin lesions of the patient.It′s application value is high.