美托洛尔治疗急性心力衰竭合并房颤的效果及对患者心功能的影响

Effect of Metoprolol in the treatment of acute heart failure complicated with atrial fibrillation and its influence on cardiac function

目的探讨美托洛尔治疗急性心力衰竭合并房颤的效果及对患者心功能的影响。方法回顾性分析2017年12月~2018年12月辽宁省盘锦市中心医院收治的120例急性心力衰竭合并房颤患者的临床资料,按照治疗方法的不同分成对照组与治疗组,每组各60例。对照组患者采用去乙酰毛花苷注射液和硝酸甘油注射液进行治疗,治疗组患者在对照组的基础上采用美托洛尔进行治疗。比较两组患者的治疗总有效率、不良反应发生率、治疗前后的心功能指标改善情况、生活质量评分情况、心力衰竭症状消失时间、心电图检查结果复常时间及住院治疗总时间。结果治疗组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗组患者的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组患者的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)低于对照组,生活质量量表(SF-36)评分和左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05)。治疗组患者的症状消失时间、心电图检查结果复常时间、住院治疗总时间短于对照组,差异有统计学意义(P<0.05)。结论急性心力衰竭合并房颤患者采用美托洛尔进行治疗,可使心功能得到大幅度改善,降低药物不良反应发生率,有效缩短病情控制时间以及患者住院时间,提高临床疗效和生活质量。

Objective To investigate the effect of Metoprolol in the treatment of acute heart failure complicated with atrial fibrillation and its influence on cardiac function.Methods Clinical data of 120 patients with acute heart failure complicated with atrial fibrillation in Panjin Central Hospital from December 2017 to December 2018 were retrospectively analyzed and divided into the control group and the treatment group according to different treatment methods,with 60 cases in each group.The control group was treated with deacetylcamoside Injection and Nitroglycerin Injection,and treatment group was treated with Metoprolol on the basis of control group.The total effective rate,the incidence of adverse reactions,the improvement of cardiac function indexes before and after treatment,the quality of life score,the disappearance time of heart failure symptoms,the return time of electrocardiogram results and the total time of hospitalization were compared between the two groups.Results The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)of the treatment group were lower than those of the control group,the quality of life scale(SF-36)score and left ventricular ejection fraction(LVEF)of the treatment group were higher than those of the control group,and the differences were statistically significant(P<0.05).The time of symptom disappearance,electrocardiogram results return to normal and total hospitalization time in the treatment group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Treatment with Metoprolol in patients with acute heart failure combined with atrial fibrillation can greatly improve cardiac function,reduce the incidence of adverse drug reactions,effectively shorten the time for disease control and the length of hospital stay of patients,and improve clinical efficacy and quality of life.