中性粒细胞/淋巴细胞比值对胰腺癌放疗预后的评估

Evaluation of Neutrophil to Lymphocyte Ratio for Prognosis of Pancreatic Cancer After Radiotherapy

目的探讨放疗前外周血中性粒细胞/淋巴细胞比值(Neutrophil to Lymphocyte Ratio,NLR)在Ⅲ期胰腺癌患者预后中的价值。方法 41例初治Ⅲ期胰腺癌患者采用ROC受试者工作特征曲线,以灵敏度和特异度最高的NLR为截断值,分为高NLR组(NLR≥2.86)和低NLR组(NLR<2.86),比较两组患者的中位生存时间并进行预后分析。结果两组患者的中位生存时间分别为9个月和21个月。Log-rank结果显示差异有统计学意义(P<0.05);中位生存时间在年龄、性别、KPS评分、肿瘤部位、血清糖类抗原19-9水平、放疗前是否行减黄或改道手术、是否伴区域淋巴结转移及同步化疗上差异无统计学意义(P>0.05);结论放疗前外周血NLR与胰腺癌患者预后密切相关,高NLR提示预后较差。

Objective To investigate the value of neutrophil to lymphocyte ratio(NLR)to evaluating the prognosis of patients with stage Ⅲ pancreatic cancer treated by radiotherapy.Methods A total of 41 patients with stage Ⅲ pancreatic cancer were detected NLR before radiotherapy.ROC curve was used to cut off the NLR with the highest sensitivity and specificity.The patients were divided into high NLR group(NLR≥2.86)and low NLR group(NLR<2.86).The survival time was recorded and compared by Log-rank method between two groups.Results The median survival time was 9 months in high NLR group and 21 months in low NLR group,showing a significant difference by Log-rank method(P<0.05).There were no significant differences in the median survival time in the age,gender,Karnofsky score,tumor location,carbohydrate antigen 19-9 level,surgical treatment before radiotherapy,regional lymph node metastasis and synchronous chemotherapy(P>0.05).Conclusion NLR is closely related to the prognosis of pancreatic cancer patients.High NLR is an indicator of poor prognosis for pancreatic cancer.