腹腔镜下胃癌根治术治疗早期胃癌的效果及对患者血清G-17、CA199、HER-2水平的影响

Effect of Laparoscopic Radical Gastrectomy for Early Gastric Cancer and Its Influence on Serum G-17,CA199 and HER-2 Levels

目的:探讨腹腔镜下胃癌根治术治疗早期胃癌的效果及对患者血清胃泌素17(G-17)、糖类抗原199(CA199)、人类表皮生长因子受体2(HER-2)水平的影响。方法:选取2018年1月-2020年2月本院收治的66例早期胃癌患者,采用随机数字表法将其分为观察组与对照组,各33例。对照组给予传统开腹胃癌根治术治疗,观察组给予腹腔镜下胃癌根治术治疗,比较两组术中及术后指标,血清G-17、CA199、HER-2水平及术后并发症。结果:观察组手术时间长于对照组,术中出血量、术后肛门排气时间、住院时间均短于对照组,差异均有统计学意义(P<0.05);两组淋巴结清扫数目比较,差异无统计学意义(P>0.05)。术后1周,两组血清G-17、CA199、HER-2水平均较术前降低,且观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组术后并发症总发生率为6.06%,低于对照组的24.24%,差异有统计学意义(P<0.05)。结论:腹腔镜下胃癌根治术治疗早期胃癌具有创伤小、术后并发症少等特点,且术后短期内血清G-17、CA199、HER-2水平下降更明显,预后更佳。

Objective:To investigate the effect of laparoscopic radical gastrectomy for early gastric cancer and its influence on serum gastrin 17(G-17),carbohydrate antigen 199(CA199),human epidermal growth factor receptor 2(HER-2)Level.Method:A total of 66 patients with early gastric cancer who were admitted to our hospital from January 2018 to February 2020 were collected,they were divided into observation group and control group by random number table method,33 cases in each group.The control group was given traditional open radical gastric cancer treatment,the observation group was given laparoscopic radical gastric cancer treatment.The intraoperative and postoperative indicators,serum G-17,CA199,HER-2 levels and postoperative complications were compared between the two groups.Result:The operation time of the observation group was longer than that of the control group,the intraoperative blood loss,postoperative anal exhaust time,and hospitalization time were shorter than that of the control group,the difference were statistically significant(P<0.05),there was no significant difference in the number of lymph node dissection between the two groups(P>0.05).1 week after operation,the serum levels of G-17,CA199 and HER-2 in the two groups were lower than those before the operation,the observation group were lower than the control group(P<0.05).The total incidence of postoperative complications in the observation group was 6.06%,which was lower than 24.24%of the control group’s,the difference was statistically significant(P<0.05).Conclusion:Laparoscopic radical gastrectomy for early gastric cancer has the characteristics of less trauma,less postoperative complications,the serum G-17,CA199,HER-2 levels decrease more significantly in the short term after surgery,the prognosis is better.