体外膜肺氧合对重症患者抗感染治疗中药动学的影响研究进展

Advances in the Study on the Effect of Extracorporeal Membrane Pulmonary Oxygenation on Anti-infective Therapy in Severe Patients

体外膜肺氧合(Extracorporeal Membrane Oxygenation,ECMO)技术是临床当中的一种医疗急救技术设备,其主要是通过体外循环这一技术来对生命进行支持的辅助治疗方式。但是患者在使用ECMO进行辅助治疗时,会影响到治疗同期所使用相关抗感染药物的药动学,使得患者的体内的血药浓度发生改变,降低治疗效果。本文主要是依据目前现有研究及证据,对重症患者在使用ECMO进行辅助治疗时,对所用抗感染药物的药动学所产生的影响及变化进行一综述,为优化ECMO辅助治疗过程中抗感染药物的使用提高理论方面的资料及基础。

Extracorporeal membrane oxygenation(ECMO)is a kind of medical first-aid equipment in clinic,which is mainly an auxiliary treatment method to support life through the technology of extracorporeal circulation.However,when patients use ECMO for adjuvant treatment,it will affect the pharmacokinetics of relevant anti infective drugs used in the same period of treatment,make the blood concentration of patients change,reduce the treatment effect.Based on the existing research and evidence,this paper reviews the influence and change of pharmacokinetics of the anti infective drugs used in the adjuvant treatment of critical patients with ECMO,in order to improve the theoretical data and basis for optimizing the use of anti infective drugs in the adjuvant treatment of ECMO.