中草药有效成分对急性重症胰腺炎病理影响基础研究文献回顾

Literature review of basic research on the effect of effective components of Chinese herbal medicine on the pathology of severe acute pancreatitis

目的:回顾总结中草药有效成分对急性重症胰腺炎病理学影响的相关基础研究。方法:通过互联网检索中国知网,主题词/关键词为"胰腺炎"and"病理",筛选有关中草药有效成分对急性重症胰腺炎病理改变影响的基础研究,精读并分析后进行汇总。结果:共检索出文献195篇,符合本次要求的文献共8篇,其中期刊文献7篇,学位论文1篇;共涉及丹参(2篇)、大黄牡丹汤、瑞香素、柴芩承气汤、红景天苷、茵陈蒿汤6种中药;实验对象为鼠类(大鼠/小鼠),观察内容涉及与急性重症胰腺炎有关因子、生化指标和病理学改变。结论:现有的胰腺炎动物模型实验证明,中草药有效成分能够通过调节炎性因子、坏死因子、生化指标、免疫学指标等改善急性重症胰腺炎病理结局。

Objective:To explore the literature review of basic research on the effect of effective components of Chinese herbal medicine on the pathology of severe acute pancreatitis.Methods:We searched CNKI through the Internet with the keywords of"pancreatitis"and"pathology",We screened the basic research about the effect of effective components of Chinese herbal medicine on the pathology of severe acute pancreatitis,read it carefully and analyzed it.Results:A total of 195 papers were retrieved,8 of which met the requirements,including 7 journal articles and 1 dissertation.Six kinds of traditional Chinese medicine were involved,including Salvia miltiorrhiza(2 articles),Dahuang Mudan Decoction,daphnetin,Chaiqin Chengqi Decoction,salidroside and Yinchenhao Decoction.The subjects were rats(rats/mice),the content of observation involved the factors,biochemical indexes and pathological changes related to severe acute pancreatitis.Conclusion:The existing animal models of pancreatitis have proved that the effective components of Chinese herbal medicine can improve the pathological outcome of severe acute pancreatitis by regulating inflammatory factors,necrosis factors,biochemical indicators and immunological indicators.